The Maastricht Acquisition Platform for Studying Mechanisms of Cell–Matrix Crosstalk (MAPEX): An Interdisciplinary and Systems Approach towards Understanding Thoracic Aortic Disease

Current management guidelines for ascending thoracic aortic aneurysms (aTAA) recommend intervention once ascending or sinus diameter reaches 5–5.5 cm or shows a growth rate of >0.5 cm/year estimated from echo/CT/MRI. However, many aTAA dissections (aTAAD) occur in vessels with diameters below the...

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Veröffentlicht in:	Biomedicines 2023-07, Vol.11 (8), p.2095
Hauptverfasser:	Ganizada, Berta H, Reesink, Koen D, Parikh, Shaiv, Ramaekers, Mitch J. F. G, Akbulut, Asim C, Saraber, Pepijn J. M. H, Debeij, Gijs P, Jaminon, Armand M, Natour, Ehsan, Lorusso, Roberto, Wildberger, Joachim E, Mees, Barend, Schurink, Geert Willem, Jacobs, Michael J, Cleutjens, Jack, Krapels, Ingrid, Gombert, Alexander, Maessen, Jos G, Accord, Ryan, Delhaas, Tammo, Schalla, Simon, Schurgers, Leon J, Bidar, Elham
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Aneurysms Aortic aneurysms aortic dissection Blood pressure Blood vessels connective tissue disorder Coronary vessels Dissection elastin degradation Endothelium Extracellular matrix Geometry Hemodynamics Homeostasis Magnetic resonance imaging mechanobiology Pathophysiology Patients Phenotyping Regulation Risk factors Shear stress Smooth muscle smooth muscle contractility Study Protocol Thorax tissue biomechanics Tomography
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Zusammenfassung:	Current management guidelines for ascending thoracic aortic aneurysms (aTAA) recommend intervention once ascending or sinus diameter reaches 5–5.5 cm or shows a growth rate of >0.5 cm/year estimated from echo/CT/MRI. However, many aTAA dissections (aTAAD) occur in vessels with diameters below the surgical intervention threshold of
ISSN:	2227-9059 2227-9059
DOI:	10.3390/biomedicines11082095