GLUT4 content decreases along with insulin resistance and high levels of inflammatory markers in rats with metabolic syndrome

Metabolic syndrome is characterized by insulin resistance, which is closely related to GLUT4 content in insulin-sensitive tissues. Thus, we evaluated the GLUT4 expression, insulin resistance and inflammation, characteristics of the metabolic syndrome, in an experimental model. Spontaneously hyperten...

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Veröffentlicht in:	Cardiovascular Diabetology 2012-08, Vol.11 (1), p.100-100, Article 100
Hauptverfasser:	Leguisamo, Natalia M, Lehnen, Alexandre M, Machado, Ubiratan F, Okamoto, Maristela M, Markoski, Melissa M, Pinto, Graziela H, Schaan, Beatriz D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin - blood Adipose Tissue, White - metabolism Adipose tissues Animals Animals, Newborn Biological markers Biomarkers - blood Blood Pressure C-reactive protein C-Reactive Protein - metabolism Carrier proteins Disease Models, Animal Down-Regulation Glucose transporter 4 Glucose Transporter Type 4 - metabolism Glutamate Hypertension Hypertension - blood Hypertension - complications Hypertension - physiopathology Inflammation Inflammation Mediators - blood Insulin Insulin Resistance Interleukin-6 - blood Interleukins Lipids - blood Male Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - chemically induced Metabolic Syndrome - immunology Metabolic Syndrome - metabolism Metabolic Syndrome - physiopathology Monosodium glutamate Muscle, Skeletal - metabolism Myocardium - metabolism Obesity Original Investigation Physiological aspects Proteins Rats Rats, Inbred SHR Rats, Inbred WKY Rodents Sodium Glutamate Spontaneously hypertensive rats Time Factors Tumor necrosis factor Tumor Necrosis Factor-alpha - blood Type 2 diabetes
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Zusammenfassung:	Metabolic syndrome is characterized by insulin resistance, which is closely related to GLUT4 content in insulin-sensitive tissues. Thus, we evaluated the GLUT4 expression, insulin resistance and inflammation, characteristics of the metabolic syndrome, in an experimental model. Spontaneously hypertensive neonate rats (18/group) were treated with monosodium glutamate (MetS) during 9 days, and compared with Wistar-Kyoto (C) and saline-treated SHR (H). Blood pressure (BP) and lipid levels, C-reactive protein (CRP), interleukin 6 (IL-6), TNF-α and adiponectin were evaluated. GLUT4 protein was analysed in the heart, white adipose tissue and gastrocnemius. Studies were performed at 3 (3-mo), 6 (6-mo) and 9 (9-mo) months of age. MetS rats were more insulin resistant (p
ISSN:	1475-2840 1475-2840
DOI:	10.1186/1475-2840-11-100