An Association of Galanin with some biochemical parameters in Iraqi Type II Diabetic Patients

Body's ability to produce insulin is affected by a group of chronic metabolic diseases known as diabetes. present study tried to explore whether there was any association of galanin with urea, uric acid, creatinine, albumin, globulin, total protein, albumin-to-globulin ratio, fasting glucose in patients with type 2 diabetes.This study included 43 patients, 43 healthy controls (HCs). ELISA was used to determine level of galanin. Study found that level of serum galanin in patients with T2DM was higher compared to healthy subjects (P < 0.0001), FSG was higher in patients compared to HCs (P < 0.0001). Galanin had a significant positive relationship with FSG, urea, creatinine, and globulin (P < 0.0001), but galanin was found to have a negative correlation with uric acid, T. protein, and albumin, in addition, albumin to globulin (ALB/GLB), P < 0.0001). Studied parameters found in descending order of area under receiver operating curve (AUROC): Galanin was (0.858), FSG (1), urea (0.757), uric acid (0.541), creatinine (0.507), T.Protein (0.530). ), globulin (0.586), and albumin (0.657). While (ALB/GLB) was (0.646). New values of cut-off value for studied variables have been estimated as follows, Galanin ( > 6.14 ng/mL), FSG (> 116.5 mg/dL), Urea (> 30.5 mg/dL), Uric acid (< 4.75 mg/dL), Creatinine (> 0.835 mg/dL), T. Protein (< 7.05 g/dL), Albumin (< 4.35 g/dL), Globulins (> 2.75 g/dL) and ALB/GLB (< 1.545). Conclusion: Serum galanin may be used as a biomarker in detection of T2DM and may be an effective biomarker in the diagnostic test for T2DM.