New S-alkylated 1,2,4-triazoles incorporating diphenyl sulfone moieties with potential antibacterial activity

Alkylation of the 5-{4-[(4-bromophenyl)sulfonyl]phenyl}-4-(3/4-methylphenyl)- 2,4-dihydro-3H-1,2,4-triazole-3-thiones 3a,b with various alkylation agents, i.e., ethyl bromide, phenacyl bromide and ethyl chloroacetate, afforded the S-substituted 1,2,4-triazoles 4-6a,b. The structures of these new compounds were elucidated by elemental analysis and IR, UV, 1H-NMR, 13C-NMR and MS spectroscopy. The newly synthesized products were tested for their antibacterial effects. Alkilovanjem 5-{4-[(4-bromofenil)sulfonil]fenil}-4-(3/4-metilfenil)-2,4-dihidro- -3H-1,2,4-triazol-3-tiona (3a,b) alkilujucim reagensima kao sto su etil-bromid, fenacil-bromid i etil-hloracetat dobijeni su S-supstituisani 1,2,4-triazoli 4-6a,b. Struktura ovih novih jedinjenja potvrdjena je elementalnom analizom kao i IR, UV, 1H-NMR, 13C-NMR i MS spektrima. Ispitivana je i antibakterijska aktivnost ovih jedinjenja.