Effects of ivermectin on cytokine and immunoglobulin levels in sheep
Background: Ivermectin may affect the levels of cytokines and immunoglobulins in sheep, considering that avermectins have an effect on the immune system. Objective: To determine whether ivermectin has an effect on cytokines and immunoglobulins in sheep. Methods: After administration of ivermectin to...
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| Veröffentlicht in: | Revista Colombiana de Ciencias Pecuarias 2023-10, Vol.36 (4), p.210-215 |
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| container_title | Revista Colombiana de Ciencias Pecuarias |
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| creator | Canbar, Rahmi Dik, Irmak Uslu, Muhittin Ider, Merve Arslan, Mustafa-Sedat Yazar, Enver |
| description | Background: Ivermectin may affect the levels of cytokines and immunoglobulins in sheep, considering that avermectins have an effect on the immune system. Objective: To determine whether ivermectin has an effect on cytokines and immunoglobulins in sheep. Methods: After administration of ivermectin to 10 healthy sheep, sheep-specific interferon-α, tumor necrosis factor-α, interleukin-2, interleukin-6, interleukin-10, immunoglobulin G, immunoglobulin M, and immunoglobulin E levels were measured with an ELISA reader. Results: Significant (p |
| doi_str_mv | 10.17533/udea.rccp.v36n4a5 |
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Objective: To determine whether ivermectin has an effect on cytokines and immunoglobulins in sheep. Methods: After administration of ivermectin to 10 healthy sheep, sheep-specific interferon-α, tumor necrosis factor-α, interleukin-2, interleukin-6, interleukin-10, immunoglobulin G, immunoglobulin M, and immunoglobulin E levels were measured with an ELISA reader. Results: Significant (p<0.05) fluctuations were detected in interleukin-2 and interleukin-10 levels. Transient increases (p<0.05) were measured in tumor necrosis factor-α and immunoglobulin E levels (p<0.05). Conclusion: Ivermectin may affect immune system parameters in healthy sheep; however, the effects of ivermectin administration on infected sheep should be investigated.</description><identifier>ISSN: 2256-2958</identifier><identifier>ISSN: 0120-0690</identifier><identifier>EISSN: 2256-2958</identifier><identifier>DOI: 10.17533/udea.rccp.v36n4a5</identifier><language>eng</language><publisher>Medellín: Universidad de Antioquía</publisher><subject>avermectinas ; avermectins ; Cytokines ; Enzyme-linked immunosorbent assay ; factor de necrosis tumoral ; fator de necrose tumoral ; IgG antibody ; Immune system ; immunity ; Immunoglobulin E ; Immunoglobulin G ; Immunoglobulin M ; Immunoglobulins ; imunidade ; imunoglobulina E ; imunoglobulina G ; imunoglobulina M ; inmunidad ; inmunoglobulina E ; inmunoglobulina G ; inmunoglobulina M ; interferon ; interferon-α ; interferão ; interferón ; interleucina ; interleukin ; interleukin-10 ; interleukin-2 ; interleukin-6 ; Ivermectin ; ivermectina ; Necrosis ; oveja ; ovelha ; Sheep ; tumor necrosis factor ; tumor necrosis factor-α ; Tumors</subject><ispartof>Revista Colombiana de Ciencias Pecuarias, 2023-10, Vol.36 (4), p.210-215</ispartof><rights>2023. This work is licensed under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>LICENCIA DE USO: Los documentos a texto completo incluidos en Dialnet son de acceso libre y propiedad de sus autores y/o editores. Por tanto, cualquier acto de reproducción, distribución, comunicación pública y/o transformación total o parcial requiere el consentimiento expreso y escrito de aquéllos. Cualquier enlace al texto completo de estos documentos deberá hacerse a través de la URL oficial de éstos en Dialnet. Más información: https://dialnet.unirioja.es/info/derechosOAI | INTELLECTUAL PROPERTY RIGHTS STATEMENT: Full text documents hosted by Dialnet are protected by copyright and/or related rights. This digital object is accessible without charge, but its use is subject to the licensing conditions set by its authors or editors. Unless expressly stated otherwise in the licensing conditions, you are free to linking, browsing, printing and making a copy for your own personal purposes. All other acts of reproduction and communication to the public are subject to the licensing conditions expressed by editors and authors and require consent from them. Any link to this document should be made using its official URL in Dialnet. More info: https://dialnet.unirioja.es/info/derechosOAI</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c384t-ae39146d00c4dc4dbd916713f84ddc5a5e197a2e24ac2ec0c217395236734643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,870,27901,27902</link.rule.ids></links><search><creatorcontrib>Canbar, Rahmi</creatorcontrib><creatorcontrib>Dik, Irmak</creatorcontrib><creatorcontrib>Uslu, Muhittin</creatorcontrib><creatorcontrib>Ider, Merve</creatorcontrib><creatorcontrib>Arslan, Mustafa-Sedat</creatorcontrib><creatorcontrib>Yazar, Enver</creatorcontrib><title>Effects of ivermectin on cytokine and immunoglobulin levels in sheep</title><title>Revista Colombiana de Ciencias Pecuarias</title><description>Background: Ivermectin may affect the levels of cytokines and immunoglobulins in sheep, considering that avermectins have an effect on the immune system. Objective: To determine whether ivermectin has an effect on cytokines and immunoglobulins in sheep. Methods: After administration of ivermectin to 10 healthy sheep, sheep-specific interferon-α, tumor necrosis factor-α, interleukin-2, interleukin-6, interleukin-10, immunoglobulin G, immunoglobulin M, and immunoglobulin E levels were measured with an ELISA reader. Results: Significant (p<0.05) fluctuations were detected in interleukin-2 and interleukin-10 levels. Transient increases (p<0.05) were measured in tumor necrosis factor-α and immunoglobulin E levels (p<0.05). Conclusion: Ivermectin may affect immune system parameters in healthy sheep; however, the effects of ivermectin administration on infected sheep should be investigated.</description><subject>avermectinas</subject><subject>avermectins</subject><subject>Cytokines</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>factor de necrosis tumoral</subject><subject>fator de necrose tumoral</subject><subject>IgG antibody</subject><subject>Immune system</subject><subject>immunity</subject><subject>Immunoglobulin E</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin M</subject><subject>Immunoglobulins</subject><subject>imunidade</subject><subject>imunoglobulina E</subject><subject>imunoglobulina G</subject><subject>imunoglobulina M</subject><subject>inmunidad</subject><subject>inmunoglobulina E</subject><subject>inmunoglobulina G</subject><subject>inmunoglobulina M</subject><subject>interferon</subject><subject>interferon-α</subject><subject>interferão</subject><subject>interferón</subject><subject>interleucina</subject><subject>interleukin</subject><subject>interleukin-10</subject><subject>interleukin-2</subject><subject>interleukin-6</subject><subject>Ivermectin</subject><subject>ivermectina</subject><subject>Necrosis</subject><subject>oveja</subject><subject>ovelha</subject><subject>Sheep</subject><subject>tumor necrosis factor</subject><subject>tumor necrosis factor-α</subject><subject>Tumors</subject><issn>2256-2958</issn><issn>0120-0690</issn><issn>2256-2958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><sourceid>FKZ</sourceid><sourceid>DOA</sourceid><recordid>eNpVUV1rGzEQPEoDTZP8gTwd9NmOpJXudNCX4KZNwFAofhfyai-Rc5Zc6c6Qfx_5g9LAwu7O7syyTFXdcjbnrQK4mxzZeULczffQBGnVp-pSCNXMRKf05__qL9XXnDeMqVYDXFY_HvqecMx17Gu_p7QtjQ91DDW-jfHVB6ptcLXfbqcQn4e4noYyHmhPQ65LlV-IdtfVRW-HTDfnfFWtfj6sFo-z5e9fT4v75QxBy3FmCTouG8cYSldi7TretBx6LZ1DZRXxrrWChLQoCBkK3kKnBDQtyEbCVfV0knXRbswu-a1NbyZab45ATM_GptHjQAa06LADxxk6KRx2yCXTa7K80Qioi9b3s5a3Q6Dxo9wZm4JPPm6soWzu_6wYY4XeSKUK_duJvkvx70R5NJs4pVCeN8BZy7gWoi1b4rSFKeacqP93hTNz9M0cfDMH38zZN3gHuBuOhQ</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Canbar, Rahmi</creator><creator>Dik, Irmak</creator><creator>Uslu, Muhittin</creator><creator>Ider, Merve</creator><creator>Arslan, Mustafa-Sedat</creator><creator>Yazar, Enver</creator><general>Universidad de Antioquía</general><general>Universidad de Antioquia</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>CLZPN</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M0K</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>AGMXS</scope><scope>FKZ</scope><scope>DOA</scope></search><sort><creationdate>20231001</creationdate><title>Effects of ivermectin on cytokine and immunoglobulin levels in sheep</title><author>Canbar, Rahmi ; Dik, Irmak ; Uslu, Muhittin ; Ider, Merve ; Arslan, Mustafa-Sedat ; Yazar, Enver</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-ae39146d00c4dc4dbd916713f84ddc5a5e197a2e24ac2ec0c217395236734643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>avermectinas</topic><topic>avermectins</topic><topic>Cytokines</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>factor de necrosis tumoral</topic><topic>fator de necrose tumoral</topic><topic>IgG antibody</topic><topic>Immune system</topic><topic>immunity</topic><topic>Immunoglobulin E</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin M</topic><topic>Immunoglobulins</topic><topic>imunidade</topic><topic>imunoglobulina E</topic><topic>imunoglobulina G</topic><topic>imunoglobulina M</topic><topic>inmunidad</topic><topic>inmunoglobulina E</topic><topic>inmunoglobulina G</topic><topic>inmunoglobulina M</topic><topic>interferon</topic><topic>interferon-α</topic><topic>interferão</topic><topic>interferón</topic><topic>interleucina</topic><topic>interleukin</topic><topic>interleukin-10</topic><topic>interleukin-2</topic><topic>interleukin-6</topic><topic>Ivermectin</topic><topic>ivermectina</topic><topic>Necrosis</topic><topic>oveja</topic><topic>ovelha</topic><topic>Sheep</topic><topic>tumor necrosis factor</topic><topic>tumor necrosis factor-α</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Canbar, Rahmi</creatorcontrib><creatorcontrib>Dik, Irmak</creatorcontrib><creatorcontrib>Uslu, Muhittin</creatorcontrib><creatorcontrib>Ider, Merve</creatorcontrib><creatorcontrib>Arslan, Mustafa-Sedat</creatorcontrib><creatorcontrib>Yazar, Enver</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Agricultural Science Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Latin America & Iberia Database</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Dialnet (Open Access Full Text)</collection><collection>Dialnet</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Revista Colombiana de Ciencias Pecuarias</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Canbar, Rahmi</au><au>Dik, Irmak</au><au>Uslu, Muhittin</au><au>Ider, Merve</au><au>Arslan, Mustafa-Sedat</au><au>Yazar, Enver</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of ivermectin on cytokine and immunoglobulin levels in sheep</atitle><jtitle>Revista Colombiana de Ciencias Pecuarias</jtitle><date>2023-10-01</date><risdate>2023</risdate><volume>36</volume><issue>4</issue><spage>210</spage><epage>215</epage><pages>210-215</pages><issn>2256-2958</issn><issn>0120-0690</issn><eissn>2256-2958</eissn><abstract>Background: Ivermectin may affect the levels of cytokines and immunoglobulins in sheep, considering that avermectins have an effect on the immune system. Objective: To determine whether ivermectin has an effect on cytokines and immunoglobulins in sheep. Methods: After administration of ivermectin to 10 healthy sheep, sheep-specific interferon-α, tumor necrosis factor-α, interleukin-2, interleukin-6, interleukin-10, immunoglobulin G, immunoglobulin M, and immunoglobulin E levels were measured with an ELISA reader. Results: Significant (p<0.05) fluctuations were detected in interleukin-2 and interleukin-10 levels. Transient increases (p<0.05) were measured in tumor necrosis factor-α and immunoglobulin E levels (p<0.05). Conclusion: Ivermectin may affect immune system parameters in healthy sheep; however, the effects of ivermectin administration on infected sheep should be investigated.</abstract><cop>Medellín</cop><pub>Universidad de Antioquía</pub><doi>10.17533/udea.rccp.v36n4a5</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | avermectinas avermectins Cytokines Enzyme-linked immunosorbent assay factor de necrosis tumoral fator de necrose tumoral IgG antibody Immune system immunity Immunoglobulin E Immunoglobulin G Immunoglobulin M Immunoglobulins imunidade imunoglobulina E imunoglobulina G imunoglobulina M inmunidad inmunoglobulina E inmunoglobulina G inmunoglobulina M interferon interferon-α interferão interferón interleucina interleukin interleukin-10 interleukin-2 interleukin-6 Ivermectin ivermectina Necrosis oveja ovelha Sheep tumor necrosis factor tumor necrosis factor-α Tumors |
| title | Effects of ivermectin on cytokine and immunoglobulin levels in sheep |
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