Haptoglobin Phenotypes in School-age Children Infected with Schistosoma haematobium: A case-control study
Background: Acute phase proteins (APPs), including haptoglobin (Hp), are a large and varied group of plasma proteins that can be used as biomarkers for disease diagnosis/detection/severity. Objective: The main objective was to assess the levels of haptoglobin (Hp) in serum and detect Hp phenotypes u...
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| Veröffentlicht in: | Pharmacy practice : official journal of the GRIPP (Global Research Institute of Pharmacy Practice) 2024, Vol.22 (1) |
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| creator | Alsulami, Fahad T Al Mazrouei, Nadia Al Amoodi, Abdulla Alkaabi, Maisoun Beshir, Semira Abdi Alqarni, Yousef Saeed El Khidir, Israa Yousif Elnour, Asim Ahmed Sam, Kishore Gnana Al Kubaisi, Khalid A Menon, Vineetha Nasur, Zeinab Eltoum Zaki, Hani Yousif Ahmed Salih, Kamal Eldin |
| description | Background: Acute phase proteins (APPs), including haptoglobin (Hp), are a large and varied group of plasma proteins that can be used as biomarkers for disease diagnosis/detection/severity. Objective: The main objective was to assess the levels of haptoglobin (Hp) in serum and detect Hp phenotypes using polyacrylamide gel electrophoresis in 100 school-aged children infected with Schistosoma haematobium compared with 60 healthy control. Methods: We conducted a case-control study on 160 schoolchildren (ages 9-15 years) recruited from Tayba Eltejania village, Sinar state, Sudan. Unrelated children with Schistosoma haematobium (case group 100) and unrelated healthy children (control group 60) were included, while those with both Schistosoma types were excluded. The enrolled subjects were evaluated for the levels of Hp and its phenotypes as early markers for disease severity. ELISA quantified biochemical analysis for the serum Hp level. Hp phenotypes were determined, and their frequency was compared between cases and controls. Results: The Hp 2-1 was the highest frequency among cases and controls 72/143 (50.3%), followed by Hp 2-2 (28%), while Hp 1-1 phenotype was 22%. The Hp 2-1 and Hp 2-2 frequency did not differ significantly between cases and controls, considering the Hp 1-1 as the reference group. Multiple comparisons were executed between Hp phenotypes; the differences between these groups were not statistically different. The disease severity was set according to the egg count (Group I: moderate infection ≤ 35/10 ml, Group II: severe infection ≥ 36/10 ml), the Hp 2-2 was four times more frequent in cases with severe infection considering Hp 1-1 as the reference phenotype (OR=3.85, 95% CI: 1.044-14.24). Confirming the result, Hp 2-2 was significantly associated with disease severity than Hp 1-1 and Hp 2-1 (OR= 3.77 95% CI: 1.39-10.20). Conclusion: There was evident that the egg count increased in subjects with Hp 2-2 indicating severe infection |
| doi_str_mv | 10.18549/PharmPract.2024.1.2890 |
| format | Article |
| fullrecord | <record><control><sourceid>dialnet</sourceid><recordid>TN_cdi_dialnet_primary_oai_dialnet_unirioja_es_ART0001665071</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>oai_dialnet_unirioja_es_ART0001665071</sourcerecordid><originalsourceid>FETCH-LOGICAL-d208t-8403a4a8161e30ab4be544ae1a1a6caf8e74dbf76e0807b43b79fe35b39ff38d3</originalsourceid><addsrcrecordid>eNpNjFFLwzAUhYMoOKe_wfyB1psmTVPxZQzdBgOHzudy296uGW0zmgzZv3eigk_nnI_Dx9i9gFiYVOUPmxbHfjNiFeIEEhWLODE5XLCJMEZHUqfp5b9-zW683wNoowVMmF3iIbhd50o78E1LgwunA3l-Xu9V61wX4Y74vLVdPdLAV0NDVaCaf9rQfj-sD867HnmL1GM4a479I5_xCj1FlRvC6Druw7E-3bKrBjtPd785ZR8vz9v5Mlq_Llbz2TqqEzAhMgokKjRCC5KApSopVQpJoEBdYWMoU3XZZJrAQFYqWWZ5QzItZd400tRyyp5-vLXFbqBQHEbb43gqHNrijx0HO1q3x4J8MXvbAoDQOoVMyC93fmgJ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Haptoglobin Phenotypes in School-age Children Infected with Schistosoma haematobium: A case-control study</title><source>PubMed Central Open Access</source><source>Dialnet</source><source>PubMed Central</source><creator>Alsulami, Fahad T ; Al Mazrouei, Nadia ; Al Amoodi, Abdulla ; Alkaabi, Maisoun ; Beshir, Semira Abdi ; Alqarni, Yousef Saeed ; El Khidir, Israa Yousif ; Elnour, Asim Ahmed ; Sam, Kishore Gnana ; Al Kubaisi, Khalid A ; Menon, Vineetha ; Nasur, Zeinab Eltoum ; Zaki, Hani Yousif ; Ahmed Salih, Kamal Eldin</creator><creatorcontrib>Alsulami, Fahad T ; Al Mazrouei, Nadia ; Al Amoodi, Abdulla ; Alkaabi, Maisoun ; Beshir, Semira Abdi ; Alqarni, Yousef Saeed ; El Khidir, Israa Yousif ; Elnour, Asim Ahmed ; Sam, Kishore Gnana ; Al Kubaisi, Khalid A ; Menon, Vineetha ; Nasur, Zeinab Eltoum ; Zaki, Hani Yousif ; Ahmed Salih, Kamal Eldin</creatorcontrib><description>Background: Acute phase proteins (APPs), including haptoglobin (Hp), are a large and varied group of plasma proteins that can be used as biomarkers for disease diagnosis/detection/severity. Objective: The main objective was to assess the levels of haptoglobin (Hp) in serum and detect Hp phenotypes using polyacrylamide gel electrophoresis in 100 school-aged children infected with Schistosoma haematobium compared with 60 healthy control. Methods: We conducted a case-control study on 160 schoolchildren (ages 9-15 years) recruited from Tayba Eltejania village, Sinar state, Sudan. Unrelated children with Schistosoma haematobium (case group 100) and unrelated healthy children (control group 60) were included, while those with both Schistosoma types were excluded. The enrolled subjects were evaluated for the levels of Hp and its phenotypes as early markers for disease severity. ELISA quantified biochemical analysis for the serum Hp level. Hp phenotypes were determined, and their frequency was compared between cases and controls. Results: The Hp 2-1 was the highest frequency among cases and controls 72/143 (50.3%), followed by Hp 2-2 (28%), while Hp 1-1 phenotype was 22%. The Hp 2-1 and Hp 2-2 frequency did not differ significantly between cases and controls, considering the Hp 1-1 as the reference group. Multiple comparisons were executed between Hp phenotypes; the differences between these groups were not statistically different. The disease severity was set according to the egg count (Group I: moderate infection ≤ 35/10 ml, Group II: severe infection ≥ 36/10 ml), the Hp 2-2 was four times more frequent in cases with severe infection considering Hp 1-1 as the reference phenotype (OR=3.85, 95% CI: 1.044-14.24). Confirming the result, Hp 2-2 was significantly associated with disease severity than Hp 1-1 and Hp 2-1 (OR= 3.77 95% CI: 1.39-10.20). Conclusion: There was evident that the egg count increased in subjects with Hp 2-2 indicating severe infection</description><identifier>ISSN: 1886-3655</identifier><identifier>EISSN: 1886-3655</identifier><identifier>DOI: 10.18549/PharmPract.2024.1.2890</identifier><language>eng</language><subject>age children ; haptoglobin ; haptoglobin 2 ; haptoglobin phenotypes ; schistosoma haematobium ; school</subject><ispartof>Pharmacy practice : official journal of the GRIPP (Global Research Institute of Pharmacy Practice), 2024, Vol.22 (1)</ispartof><rights>LICENCIA DE USO: Los documentos a texto completo incluidos en Dialnet son de acceso libre y propiedad de sus autores y/o editores. Por tanto, cualquier acto de reproducción, distribución, comunicación pública y/o transformación total o parcial requiere el consentimiento expreso y escrito de aquéllos. Cualquier enlace al texto completo de estos documentos deberá hacerse a través de la URL oficial de éstos en Dialnet. Más información: https://dialnet.unirioja.es/info/derechosOAI | INTELLECTUAL PROPERTY RIGHTS STATEMENT: Full text documents hosted by Dialnet are protected by copyright and/or related rights. This digital object is accessible without charge, but its use is subject to the licensing conditions set by its authors or editors. Unless expressly stated otherwise in the licensing conditions, you are free to linking, browsing, printing and making a copy for your own personal purposes. All other acts of reproduction and communication to the public are subject to the licensing conditions expressed by editors and authors and require consent from them. Any link to this document should be made using its official URL in Dialnet. More info: https://dialnet.unirioja.es/info/derechosOAI</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,872,4012,27910,27911,27912</link.rule.ids></links><search><creatorcontrib>Alsulami, Fahad T</creatorcontrib><creatorcontrib>Al Mazrouei, Nadia</creatorcontrib><creatorcontrib>Al Amoodi, Abdulla</creatorcontrib><creatorcontrib>Alkaabi, Maisoun</creatorcontrib><creatorcontrib>Beshir, Semira Abdi</creatorcontrib><creatorcontrib>Alqarni, Yousef Saeed</creatorcontrib><creatorcontrib>El Khidir, Israa Yousif</creatorcontrib><creatorcontrib>Elnour, Asim Ahmed</creatorcontrib><creatorcontrib>Sam, Kishore Gnana</creatorcontrib><creatorcontrib>Al Kubaisi, Khalid A</creatorcontrib><creatorcontrib>Menon, Vineetha</creatorcontrib><creatorcontrib>Nasur, Zeinab Eltoum</creatorcontrib><creatorcontrib>Zaki, Hani Yousif</creatorcontrib><creatorcontrib>Ahmed Salih, Kamal Eldin</creatorcontrib><title>Haptoglobin Phenotypes in School-age Children Infected with Schistosoma haematobium: A case-control study</title><title>Pharmacy practice : official journal of the GRIPP (Global Research Institute of Pharmacy Practice)</title><description>Background: Acute phase proteins (APPs), including haptoglobin (Hp), are a large and varied group of plasma proteins that can be used as biomarkers for disease diagnosis/detection/severity. Objective: The main objective was to assess the levels of haptoglobin (Hp) in serum and detect Hp phenotypes using polyacrylamide gel electrophoresis in 100 school-aged children infected with Schistosoma haematobium compared with 60 healthy control. Methods: We conducted a case-control study on 160 schoolchildren (ages 9-15 years) recruited from Tayba Eltejania village, Sinar state, Sudan. Unrelated children with Schistosoma haematobium (case group 100) and unrelated healthy children (control group 60) were included, while those with both Schistosoma types were excluded. The enrolled subjects were evaluated for the levels of Hp and its phenotypes as early markers for disease severity. ELISA quantified biochemical analysis for the serum Hp level. Hp phenotypes were determined, and their frequency was compared between cases and controls. Results: The Hp 2-1 was the highest frequency among cases and controls 72/143 (50.3%), followed by Hp 2-2 (28%), while Hp 1-1 phenotype was 22%. The Hp 2-1 and Hp 2-2 frequency did not differ significantly between cases and controls, considering the Hp 1-1 as the reference group. Multiple comparisons were executed between Hp phenotypes; the differences between these groups were not statistically different. The disease severity was set according to the egg count (Group I: moderate infection ≤ 35/10 ml, Group II: severe infection ≥ 36/10 ml), the Hp 2-2 was four times more frequent in cases with severe infection considering Hp 1-1 as the reference phenotype (OR=3.85, 95% CI: 1.044-14.24). Confirming the result, Hp 2-2 was significantly associated with disease severity than Hp 1-1 and Hp 2-1 (OR= 3.77 95% CI: 1.39-10.20). Conclusion: There was evident that the egg count increased in subjects with Hp 2-2 indicating severe infection</description><subject>age children</subject><subject>haptoglobin</subject><subject>haptoglobin 2</subject><subject>haptoglobin phenotypes</subject><subject>schistosoma haematobium</subject><subject>school</subject><issn>1886-3655</issn><issn>1886-3655</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>FKZ</sourceid><recordid>eNpNjFFLwzAUhYMoOKe_wfyB1psmTVPxZQzdBgOHzudy296uGW0zmgzZv3eigk_nnI_Dx9i9gFiYVOUPmxbHfjNiFeIEEhWLODE5XLCJMEZHUqfp5b9-zW683wNoowVMmF3iIbhd50o78E1LgwunA3l-Xu9V61wX4Y74vLVdPdLAV0NDVaCaf9rQfj-sD867HnmL1GM4a479I5_xCj1FlRvC6Druw7E-3bKrBjtPd785ZR8vz9v5Mlq_Llbz2TqqEzAhMgokKjRCC5KApSopVQpJoEBdYWMoU3XZZJrAQFYqWWZ5QzItZd400tRyyp5-vLXFbqBQHEbb43gqHNrijx0HO1q3x4J8MXvbAoDQOoVMyC93fmgJ</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Alsulami, Fahad T</creator><creator>Al Mazrouei, Nadia</creator><creator>Al Amoodi, Abdulla</creator><creator>Alkaabi, Maisoun</creator><creator>Beshir, Semira Abdi</creator><creator>Alqarni, Yousef Saeed</creator><creator>El Khidir, Israa Yousif</creator><creator>Elnour, Asim Ahmed</creator><creator>Sam, Kishore Gnana</creator><creator>Al Kubaisi, Khalid A</creator><creator>Menon, Vineetha</creator><creator>Nasur, Zeinab Eltoum</creator><creator>Zaki, Hani Yousif</creator><creator>Ahmed Salih, Kamal Eldin</creator><scope>AGMXS</scope><scope>FKZ</scope></search><sort><creationdate>2024</creationdate><title>Haptoglobin Phenotypes in School-age Children Infected with Schistosoma haematobium: A case-control study</title><author>Alsulami, Fahad T ; Al Mazrouei, Nadia ; Al Amoodi, Abdulla ; Alkaabi, Maisoun ; Beshir, Semira Abdi ; Alqarni, Yousef Saeed ; El Khidir, Israa Yousif ; Elnour, Asim Ahmed ; Sam, Kishore Gnana ; Al Kubaisi, Khalid A ; Menon, Vineetha ; Nasur, Zeinab Eltoum ; Zaki, Hani Yousif ; Ahmed Salih, Kamal Eldin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-d208t-8403a4a8161e30ab4be544ae1a1a6caf8e74dbf76e0807b43b79fe35b39ff38d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>age children</topic><topic>haptoglobin</topic><topic>haptoglobin 2</topic><topic>haptoglobin phenotypes</topic><topic>schistosoma haematobium</topic><topic>school</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alsulami, Fahad T</creatorcontrib><creatorcontrib>Al Mazrouei, Nadia</creatorcontrib><creatorcontrib>Al Amoodi, Abdulla</creatorcontrib><creatorcontrib>Alkaabi, Maisoun</creatorcontrib><creatorcontrib>Beshir, Semira Abdi</creatorcontrib><creatorcontrib>Alqarni, Yousef Saeed</creatorcontrib><creatorcontrib>El Khidir, Israa Yousif</creatorcontrib><creatorcontrib>Elnour, Asim Ahmed</creatorcontrib><creatorcontrib>Sam, Kishore Gnana</creatorcontrib><creatorcontrib>Al Kubaisi, Khalid A</creatorcontrib><creatorcontrib>Menon, Vineetha</creatorcontrib><creatorcontrib>Nasur, Zeinab Eltoum</creatorcontrib><creatorcontrib>Zaki, Hani Yousif</creatorcontrib><creatorcontrib>Ahmed Salih, Kamal Eldin</creatorcontrib><collection>Dialnet (Open Access Full Text)</collection><collection>Dialnet</collection><jtitle>Pharmacy practice : official journal of the GRIPP (Global Research Institute of Pharmacy Practice)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alsulami, Fahad T</au><au>Al Mazrouei, Nadia</au><au>Al Amoodi, Abdulla</au><au>Alkaabi, Maisoun</au><au>Beshir, Semira Abdi</au><au>Alqarni, Yousef Saeed</au><au>El Khidir, Israa Yousif</au><au>Elnour, Asim Ahmed</au><au>Sam, Kishore Gnana</au><au>Al Kubaisi, Khalid A</au><au>Menon, Vineetha</au><au>Nasur, Zeinab Eltoum</au><au>Zaki, Hani Yousif</au><au>Ahmed Salih, Kamal Eldin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Haptoglobin Phenotypes in School-age Children Infected with Schistosoma haematobium: A case-control study</atitle><jtitle>Pharmacy practice : official journal of the GRIPP (Global Research Institute of Pharmacy Practice)</jtitle><date>2024</date><risdate>2024</risdate><volume>22</volume><issue>1</issue><issn>1886-3655</issn><eissn>1886-3655</eissn><abstract>Background: Acute phase proteins (APPs), including haptoglobin (Hp), are a large and varied group of plasma proteins that can be used as biomarkers for disease diagnosis/detection/severity. Objective: The main objective was to assess the levels of haptoglobin (Hp) in serum and detect Hp phenotypes using polyacrylamide gel electrophoresis in 100 school-aged children infected with Schistosoma haematobium compared with 60 healthy control. Methods: We conducted a case-control study on 160 schoolchildren (ages 9-15 years) recruited from Tayba Eltejania village, Sinar state, Sudan. Unrelated children with Schistosoma haematobium (case group 100) and unrelated healthy children (control group 60) were included, while those with both Schistosoma types were excluded. The enrolled subjects were evaluated for the levels of Hp and its phenotypes as early markers for disease severity. ELISA quantified biochemical analysis for the serum Hp level. Hp phenotypes were determined, and their frequency was compared between cases and controls. Results: The Hp 2-1 was the highest frequency among cases and controls 72/143 (50.3%), followed by Hp 2-2 (28%), while Hp 1-1 phenotype was 22%. The Hp 2-1 and Hp 2-2 frequency did not differ significantly between cases and controls, considering the Hp 1-1 as the reference group. Multiple comparisons were executed between Hp phenotypes; the differences between these groups were not statistically different. The disease severity was set according to the egg count (Group I: moderate infection ≤ 35/10 ml, Group II: severe infection ≥ 36/10 ml), the Hp 2-2 was four times more frequent in cases with severe infection considering Hp 1-1 as the reference phenotype (OR=3.85, 95% CI: 1.044-14.24). Confirming the result, Hp 2-2 was significantly associated with disease severity than Hp 1-1 and Hp 2-1 (OR= 3.77 95% CI: 1.39-10.20). Conclusion: There was evident that the egg count increased in subjects with Hp 2-2 indicating severe infection</abstract><doi>10.18549/PharmPract.2024.1.2890</doi><oa>free_for_read</oa></addata></record> |
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| subjects | age children haptoglobin haptoglobin 2 haptoglobin phenotypes schistosoma haematobium school |
| title | Haptoglobin Phenotypes in School-age Children Infected with Schistosoma haematobium: A case-control study |
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