Panorama genómico y citogenético de las leucemias mieloides agudas con anormalidades genéticas recurrentes
Las leucemias mieloides agudas son un grupo heterogéneo de enfermedades caracterizadas por un aumento de células inmaduras. Inicialmente, fueron clasificadas teniendo en cuenta datos morfológicos; sin embargo, con tas nuevas herramientas diagnósticas se establece una clasificación más completa que c...
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description | Las leucemias mieloides agudas son un grupo heterogéneo de enfermedades caracterizadas por un aumento de células inmaduras. Inicialmente, fueron clasificadas teniendo en cuenta datos morfológicos; sin embargo, con tas nuevas herramientas diagnósticas se establece una clasificación más completa que comprende grupos de alteraciones cromosómicas y mutaciones genéticas a tas cuates se dirige el tratamiento. Se asocian con mutaciones genéticas adicionales que, en la mayoría de tos casos, confieren características desfavorables a tos pacientes y en muchas ocasiones se traducen en bajas tasas de remisión completa y recaídas frecuentes. Palabras claves: Leucemia mieloide aguda; Mutación; Genética; Anormalidades citogenéticas; Pronóstico. Acute myeloid leukemias are a heterogeneous group of diseases characterized by an increase in immature celts. Initially, acute myeloid leukemias were classified taking into account morphological data; however, with new diagnostic tools a more complete classification is established and comprising groups of chromosomal alterations and genetic mutations to which treatment is directed. Acute myeloid leukemias are associated with additional genetic mutations, which, in most cases, confer unfavorable characteristics to patients and often result in low rates of complete remission and frequent relapses. Keywords: Acute myeloid leukemia; Mutation; Genetic; Cytogenetic abnormalities; Prognosis. |
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Inicialmente, fueron clasificadas teniendo en cuenta datos morfológicos; sin embargo, con tas nuevas herramientas diagnósticas se establece una clasificación más completa que comprende grupos de alteraciones cromosómicas y mutaciones genéticas a tas cuates se dirige el tratamiento. Se asocian con mutaciones genéticas adicionales que, en la mayoría de tos casos, confieren características desfavorables a tos pacientes y en muchas ocasiones se traducen en bajas tasas de remisión completa y recaídas frecuentes. Palabras claves: Leucemia mieloide aguda; Mutación; Genética; Anormalidades citogenéticas; Pronóstico. Acute myeloid leukemias are a heterogeneous group of diseases characterized by an increase in immature celts. Initially, acute myeloid leukemias were classified taking into account morphological data; however, with new diagnostic tools a more complete classification is established and comprising groups of chromosomal alterations and genetic mutations to which treatment is directed. Acute myeloid leukemias are associated with additional genetic mutations, which, in most cases, confer unfavorable characteristics to patients and often result in low rates of complete remission and frequent relapses. Keywords: Acute myeloid leukemia; Mutation; Genetic; Cytogenetic abnormalities; Prognosis.</description><identifier>ISSN: 0120-8705</identifier><identifier>EISSN: 2215-9177</identifier><identifier>DOI: 10.21615/cesmedicina.34.2.4</identifier><language>spa</language><publisher>Medellín: Universidad del CES</publisher><subject>Anormalidades citogenéticas ; Cytogenetics ; Genética ; Kinases ; Leucemia mieloide aguda ; Leukemia ; Medical prognosis ; MEDICINE, GENERAL & INTERNAL ; Mutación ; Mutation ; Pronóstico</subject><ispartof>C.E.S. medicina, 2020-05, Vol.34 (2), p.126-135</ispartof><rights>COPYRIGHT 2020 Universidad del CES</rights><rights>Copyright Universidad CES May-Aug 2020</rights><rights>This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.</rights><rights>LICENCIA DE USO: Los documentos a texto completo incluidos en Dialnet son de acceso libre y propiedad de sus autores y/o editores. 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Any link to this document should be made using its official URL in Dialnet. More info: https://dialnet.unirioja.es/info/derechosOAI</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2626-82a5fc2eef9d51f1916217f4e464f903be5d3a097ccb8e28312d13d173ae997f3</cites><orcidid>0000-0002-2163-3507 ; 0000-0003-1503-5532</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,874,885,27924,27925</link.rule.ids></links><search><creatorcontrib>Acevedo Toro, Paola Andrea</creatorcontrib><creatorcontrib>Yuleza Pino Palacios, Erika</creatorcontrib><title>Panorama genómico y citogenético de las leucemias mieloides agudas con anormalidades genéticas recurrentes</title><title>C.E.S. medicina</title><addtitle>CES Med</addtitle><description>Las leucemias mieloides agudas son un grupo heterogéneo de enfermedades caracterizadas por un aumento de células inmaduras. Inicialmente, fueron clasificadas teniendo en cuenta datos morfológicos; sin embargo, con tas nuevas herramientas diagnósticas se establece una clasificación más completa que comprende grupos de alteraciones cromosómicas y mutaciones genéticas a tas cuates se dirige el tratamiento. Se asocian con mutaciones genéticas adicionales que, en la mayoría de tos casos, confieren características desfavorables a tos pacientes y en muchas ocasiones se traducen en bajas tasas de remisión completa y recaídas frecuentes. Palabras claves: Leucemia mieloide aguda; Mutación; Genética; Anormalidades citogenéticas; Pronóstico. Acute myeloid leukemias are a heterogeneous group of diseases characterized by an increase in immature celts. Initially, acute myeloid leukemias were classified taking into account morphological data; however, with new diagnostic tools a more complete classification is established and comprising groups of chromosomal alterations and genetic mutations to which treatment is directed. Acute myeloid leukemias are associated with additional genetic mutations, which, in most cases, confer unfavorable characteristics to patients and often result in low rates of complete remission and frequent relapses. Keywords: Acute myeloid leukemia; Mutation; Genetic; Cytogenetic abnormalities; Prognosis.</description><subject>Anormalidades citogenéticas</subject><subject>Cytogenetics</subject><subject>Genética</subject><subject>Kinases</subject><subject>Leucemia mieloide aguda</subject><subject>Leukemia</subject><subject>Medical prognosis</subject><subject>MEDICINE, GENERAL & INTERNAL</subject><subject>Mutación</subject><subject>Mutation</subject><subject>Pronóstico</subject><issn>0120-8705</issn><issn>2215-9177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>FKZ</sourceid><recordid>eNpVks1q3DAQx01poUuaJ-jFUOjNrjSSv6CXJfQLAiltehYTabTRYkupZB_ySD33EfpilbtNNiuBPmbmN5L-mqJ4zVkNvOXNO01pIuO081gLWUMtnxUbAN5UA--658WGcWBV37HmZXGe0p7lJgcBvdwU01f0IeKE5Y78n9-T06G8L7Wbw7r_Na97Q-WIqRxp0TS5vJocjcEZSiXuFpMNOvhyzTPh6Ayujgc6OyPpJUbyM6VXxQuLY6Lz__NZ8ePjh-uLz9Xl1acvF9vLSkMLbdUDNlYDkR1Mwy0feAu8s5JkK-3AxA01RiAbOq1veoJecDBcGN4JpGHorDgr3h_yGoejp1ndRTdhvFcBnXqwLd5FF_aoKKntt-ssCped7IFlvD7gSa8vVfuwRJ_vq76vSqpVSWCwypgHDm0G3hyAuxh-LpTmIwKN6HjTMMGOUTscSTlvwxxRTy5ptW2lEAJYC8fDT6JyN7T-jifrsv0EePsEuCUc59sUxmV2wafTQHEI1DGkFMk-ysKZ-ldK6kkpKSEVKCn-Asn6vjY</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Acevedo Toro, Paola Andrea</creator><creator>Yuleza Pino Palacios, Erika</creator><general>Universidad del CES</general><general>Universidad CES</general><scope>AAYXX</scope><scope>CITATION</scope><scope>INF</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CLZPN</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>GPN</scope><scope>AGMXS</scope><scope>FKZ</scope><orcidid>https://orcid.org/0000-0002-2163-3507</orcidid><orcidid>https://orcid.org/0000-0003-1503-5532</orcidid></search><sort><creationdate>20200501</creationdate><title>Panorama genómico y citogenético de las leucemias mieloides agudas con anormalidades genéticas recurrentes</title><author>Acevedo Toro, Paola Andrea ; Yuleza Pino Palacios, Erika</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2626-82a5fc2eef9d51f1916217f4e464f903be5d3a097ccb8e28312d13d173ae997f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2020</creationdate><topic>Anormalidades citogenéticas</topic><topic>Cytogenetics</topic><topic>Genética</topic><topic>Kinases</topic><topic>Leucemia mieloide aguda</topic><topic>Leukemia</topic><topic>Medical prognosis</topic><topic>MEDICINE, GENERAL & INTERNAL</topic><topic>Mutación</topic><topic>Mutation</topic><topic>Pronóstico</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Acevedo Toro, Paola Andrea</creatorcontrib><creatorcontrib>Yuleza Pino Palacios, Erika</creatorcontrib><collection>CrossRef</collection><collection>Gale OneFile: Informe Academico</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Latin America & Iberia Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>SciELO</collection><collection>Dialnet (Open Access Full Text)</collection><collection>Dialnet</collection><jtitle>C.E.S. medicina</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Acevedo Toro, Paola Andrea</au><au>Yuleza Pino Palacios, Erika</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Panorama genómico y citogenético de las leucemias mieloides agudas con anormalidades genéticas recurrentes</atitle><jtitle>C.E.S. medicina</jtitle><addtitle>CES Med</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>34</volume><issue>2</issue><spage>126</spage><epage>135</epage><pages>126-135</pages><issn>0120-8705</issn><eissn>2215-9177</eissn><abstract>Las leucemias mieloides agudas son un grupo heterogéneo de enfermedades caracterizadas por un aumento de células inmaduras. Inicialmente, fueron clasificadas teniendo en cuenta datos morfológicos; sin embargo, con tas nuevas herramientas diagnósticas se establece una clasificación más completa que comprende grupos de alteraciones cromosómicas y mutaciones genéticas a tas cuates se dirige el tratamiento. Se asocian con mutaciones genéticas adicionales que, en la mayoría de tos casos, confieren características desfavorables a tos pacientes y en muchas ocasiones se traducen en bajas tasas de remisión completa y recaídas frecuentes. Palabras claves: Leucemia mieloide aguda; Mutación; Genética; Anormalidades citogenéticas; Pronóstico. Acute myeloid leukemias are a heterogeneous group of diseases characterized by an increase in immature celts. Initially, acute myeloid leukemias were classified taking into account morphological data; however, with new diagnostic tools a more complete classification is established and comprising groups of chromosomal alterations and genetic mutations to which treatment is directed. Acute myeloid leukemias are associated with additional genetic mutations, which, in most cases, confer unfavorable characteristics to patients and often result in low rates of complete remission and frequent relapses. Keywords: Acute myeloid leukemia; Mutation; Genetic; Cytogenetic abnormalities; Prognosis.</abstract><cop>Medellín</cop><pub>Universidad del CES</pub><doi>10.21615/cesmedicina.34.2.4</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-2163-3507</orcidid><orcidid>https://orcid.org/0000-0003-1503-5532</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Anormalidades citogenéticas Cytogenetics Genética Kinases Leucemia mieloide aguda Leukemia Medical prognosis MEDICINE, GENERAL & INTERNAL Mutación Mutation Pronóstico |
title | Panorama genómico y citogenético de las leucemias mieloides agudas con anormalidades genéticas recurrentes |
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