Panorama genómico y citogenético de las leucemias mieloides agudas con anormalidades genéticas recurrentes

Las leucemias mieloides agudas son un grupo heterogéneo de enfermedades caracterizadas por un aumento de células inmaduras. Inicialmente, fueron clasificadas teniendo en cuenta datos morfológicos; sin embargo, con tas nuevas herramientas diagnósticas se establece una clasificación más completa que c...

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Veröffentlicht in:C.E.S. medicina 2020-05, Vol.34 (2), p.126-135
Hauptverfasser: Acevedo Toro, Paola Andrea, Yuleza Pino Palacios, Erika
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Yuleza Pino Palacios, Erika
description Las leucemias mieloides agudas son un grupo heterogéneo de enfermedades caracterizadas por un aumento de células inmaduras. Inicialmente, fueron clasificadas teniendo en cuenta datos morfológicos; sin embargo, con tas nuevas herramientas diagnósticas se establece una clasificación más completa que comprende grupos de alteraciones cromosómicas y mutaciones genéticas a tas cuates se dirige el tratamiento. Se asocian con mutaciones genéticas adicionales que, en la mayoría de tos casos, confieren características desfavorables a tos pacientes y en muchas ocasiones se traducen en bajas tasas de remisión completa y recaídas frecuentes. Palabras claves: Leucemia mieloide aguda; Mutación; Genética; Anormalidades citogenéticas; Pronóstico. Acute myeloid leukemias are a heterogeneous group of diseases characterized by an increase in immature celts. Initially, acute myeloid leukemias were classified taking into account morphological data; however, with new diagnostic tools a more complete classification is established and comprising groups of chromosomal alterations and genetic mutations to which treatment is directed. Acute myeloid leukemias are associated with additional genetic mutations, which, in most cases, confer unfavorable characteristics to patients and often result in low rates of complete remission and frequent relapses. Keywords: Acute myeloid leukemia; Mutation; Genetic; Cytogenetic abnormalities; Prognosis.
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Inicialmente, fueron clasificadas teniendo en cuenta datos morfológicos; sin embargo, con tas nuevas herramientas diagnósticas se establece una clasificación más completa que comprende grupos de alteraciones cromosómicas y mutaciones genéticas a tas cuates se dirige el tratamiento. Se asocian con mutaciones genéticas adicionales que, en la mayoría de tos casos, confieren características desfavorables a tos pacientes y en muchas ocasiones se traducen en bajas tasas de remisión completa y recaídas frecuentes. Palabras claves: Leucemia mieloide aguda; Mutación; Genética; Anormalidades citogenéticas; Pronóstico. Acute myeloid leukemias are a heterogeneous group of diseases characterized by an increase in immature celts. Initially, acute myeloid leukemias were classified taking into account morphological data; however, with new diagnostic tools a more complete classification is established and comprising groups of chromosomal alterations and genetic mutations to which treatment is directed. Acute myeloid leukemias are associated with additional genetic mutations, which, in most cases, confer unfavorable characteristics to patients and often result in low rates of complete remission and frequent relapses. 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Inicialmente, fueron clasificadas teniendo en cuenta datos morfológicos; sin embargo, con tas nuevas herramientas diagnósticas se establece una clasificación más completa que comprende grupos de alteraciones cromosómicas y mutaciones genéticas a tas cuates se dirige el tratamiento. Se asocian con mutaciones genéticas adicionales que, en la mayoría de tos casos, confieren características desfavorables a tos pacientes y en muchas ocasiones se traducen en bajas tasas de remisión completa y recaídas frecuentes. Palabras claves: Leucemia mieloide aguda; Mutación; Genética; Anormalidades citogenéticas; Pronóstico. Acute myeloid leukemias are a heterogeneous group of diseases characterized by an increase in immature celts. Initially, acute myeloid leukemias were classified taking into account morphological data; however, with new diagnostic tools a more complete classification is established and comprising groups of chromosomal alterations and genetic mutations to which treatment is directed. Acute myeloid leukemias are associated with additional genetic mutations, which, in most cases, confer unfavorable characteristics to patients and often result in low rates of complete remission and frequent relapses. Keywords: Acute myeloid leukemia; Mutation; Genetic; Cytogenetic abnormalities; Prognosis.</abstract><cop>Medellín</cop><pub>Universidad del CES</pub><doi>10.21615/cesmedicina.34.2.4</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-2163-3507</orcidid><orcidid>https://orcid.org/0000-0003-1503-5532</orcidid><oa>free_for_read</oa></addata></record>
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subjects Anormalidades citogenéticas
Cytogenetics
Genética
Kinases
Leucemia mieloide aguda
Leukemia
Medical prognosis
MEDICINE, GENERAL & INTERNAL
Mutación
Mutation
Pronóstico
title Panorama genómico y citogenético de las leucemias mieloides agudas con anormalidades genéticas recurrentes
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