I-SPY 2 Breast Dynamic Contrast Enhanced MRI (I-SPY2 TRIAL)
I-SPY 2 (Investigation of Serial studies to Predict Your Therapeutic Response with Imaging And moLecular analysis 2) is an ongoing, multi-center trial designed to quickly evaluate the efficacy of new agents for breast cancer in neoadjuvant chemotherapy (NAC) setting. Women aged ≥18 years diagnosed w...
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| creator | Li, Wen Newitt, David C. Gibbs, Jessica Wilmes, Lisa J. Jones, Ella F. Arasu, Vignesh A. Strand, Fredrik Onishi, Natsuko Nguyen, Alex Anh-Tu Kornak, John Joe, Bonnie N. Price, Elissa R. Ojeda-Fournier, Haydee Eghtedari, Mohammad Zamora, Kathryn W. Woodard, Stefanie A. Umphrey, Heidi Bernreuter, Wanda Nelson, Michael Church, An Ly Bolan, Patrick Kuritza, Theresa Ward, Kathleen Morley, Kevin Wolverton, Dulcy Fountain, Kelly Lopez-Paniagua, Dan Hardesty, Lara Brandt, Kathy McDonald, Elizabeth S. Rosen, Mark Kontos, Despina Abe, Hiroyuki Sheth, Deepa Crane, Erin P. Dillis, Charlotte Sheth, Pulin Hovanessian-Larsen, Linda Bang, Dae Hee Porter, Bruce Oh, Karen Y. Jafarian, Neda Tudorica, Alina Niell, Bethany L. Drukteinis, Jennifer Newell, Mary S. Cohen, Michael A. Giurescu, Marina Berman, Elise Lehman, Constance Partridge, Savannah C. Fitzpatrick, Kimberly A. Borders, Marisa H. Yang, Wei T. Dogan, Basak Goudreau, Sally Chenevert, Thomas Yau, Christina DeMichele, Angela Berry, Don Esserman, Laura J. Hylton, Nola M. |
| description | I-SPY 2 (Investigation of Serial studies to Predict Your Therapeutic Response with Imaging And moLecular analysis 2) is an ongoing, multi-center trial designed to quickly evaluate the efficacy of new agents for breast cancer in neoadjuvant chemotherapy (NAC) setting. Women aged ≥18 years diagnosed with locally advanced breast cancer (tumor size ≥2.5 cm) without distant metastasis are eligible to enroll in the trial. Patients with breast cancer at high-risk for recurrence are adaptively-randomized to either control arm (standard NAC) or one of several concurrent experimental drug arms. I-SPY 2 utilizes change in tumor volume by DCE-MRI at serial time-points during NAC to adjust the randomization schema as the trial proceeds, preferentially assigning patients to receive agents showing an increasing likelihood of efficacy against their breast cancer subtype. |
| doi_str_mv | 10.7937/tcia.d8z0-9t85 |
| format | Dataset |
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| identifier | DOI: 10.7937/tcia.d8z0-9t85 |
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| language | eng |
| recordid | cdi_datacite_primary_10_7937_tcia_d8z0_9t85 |
| source | DataCite |
| title | I-SPY 2 Breast Dynamic Contrast Enhanced MRI (I-SPY2 TRIAL) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T07%3A28%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-datacite_PQ8&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=unknown&rft.au=Li,%20Wen&rft.date=2022&rft_id=info:doi/10.7937/tcia.d8z0-9t85&rft_dat=%3Cdatacite_PQ8%3E10_7937_tcia_d8z0_9t85%3C/datacite_PQ8%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |