Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

Major depression is a debilitating psychiatric illness that is typically associated with low mood, anhedonia and a range of comorbidities. Depression has a heritable component that has remained difficult to elucidate with current sample sizes due to the polygenic nature of the disorder. To maximise...

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Hauptverfasser:	Howard, David, Adams, Mark, Clarke, Toni-Kim, Hafferty, Jonathan, Gibson, Jude, Shirali, Masoud, Coleman, Jonathan, Ward, Joey, Wigmore, Eleanor, Alloza, Clara, Shen, Xueyi, Barbu, Miruna, Xu, Eileen, Whalley, Heather, Marioni, Riccardo, Porteous, David, Davies, Gail, Deary, Ian, Hemani, Gibran, Tian, Chao, Hinds, David, 23andMe Research Team, Consortium, Major Depressive Disorder Working Group Of The Psychiatric Genomics, Trzaskowshi, Maciej, Byrne, Enda, Ripke, Stephan, Smith, Daniel, Sullivan, Patrick, Wray, Naomi, Breen, Gerome, Lewis, Cathryn, McIntosh, Andrew
Format:	Dataset
Sprache:	eng
Schlagworte:	andMe Biological Sciences::Human Genetics depression meta-analysis Psychiatric Genomics Consortium UK Biobank
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