Chronic kidney disease is a main confounding factor for 25-vitamin D measurement
Abstract Background: Current guidelines recommend assessment of 25-vitamin D status in patients with chronic kidney disease (CKD). Although significant differences among assays have been described, the impact of CKD on this variability has never been tested. Methods: We tested the variability betwee...
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creator | Machado, Hanna Karla Andrade Guapyassú Martins, Carolina Steller Wagner Jorgetti, Vanda Rosilene Motta Elias Moysés, Rosa Maria Affonso |
description | Abstract Background: Current guidelines recommend assessment of 25-vitamin D status in patients with chronic kidney disease (CKD). Although significant differences among assays have been described, the impact of CKD on this variability has never been tested. Methods: We tested the variability between two 25-vitamin D assays in patients with CKD (eGFR < 60 mL/min/1.73m2) who had consecutive 25-vitamin D measurements in 2015 (Assay 1 - Diasorin LIASON 25 TOTAL - D assay®) and 2016 (Assay 2 - Beckman Coulter Unicel Xl 800®). The cohort consisted of 791 adult patients (122 with normal renal function and 669 with CKD - 33, 30, and 37% in stages 3, 4, and 5 on dialysis, respectively). Results: Levels of 25-vitamin D were lower and the prevalence of hypovitaminosis D using assay 1 was higher than using assay 2 in patients with CKD, regardless of similar levels of calcium, phosphate, and parathyroid hormone. As kidney function decreased, the percentage of disagreement between the assays increased. Conclusion: There is a noteworthy variability between assays in patients with CKD such that the diagnosis of hypovitaminosis D is modified. The mechanism behind this result is still unclear and might be due to a possible interference in the analytical process. However, the clinical significance is unquestionable, as the supplementation of vitamin D can be erroneously prescribed to these patients. |
doi_str_mv | 10.6084/m9.figshare.9927899 |
format | Dataset |
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Although significant differences among assays have been described, the impact of CKD on this variability has never been tested. Methods: We tested the variability between two 25-vitamin D assays in patients with CKD (eGFR < 60 mL/min/1.73m2) who had consecutive 25-vitamin D measurements in 2015 (Assay 1 - Diasorin LIASON 25 TOTAL - D assay®) and 2016 (Assay 2 - Beckman Coulter Unicel Xl 800®). The cohort consisted of 791 adult patients (122 with normal renal function and 669 with CKD - 33, 30, and 37% in stages 3, 4, and 5 on dialysis, respectively). Results: Levels of 25-vitamin D were lower and the prevalence of hypovitaminosis D using assay 1 was higher than using assay 2 in patients with CKD, regardless of similar levels of calcium, phosphate, and parathyroid hormone. As kidney function decreased, the percentage of disagreement between the assays increased. Conclusion: There is a noteworthy variability between assays in patients with CKD such that the diagnosis of hypovitaminosis D is modified. The mechanism behind this result is still unclear and might be due to a possible interference in the analytical process. However, the clinical significance is unquestionable, as the supplementation of vitamin D can be erroneously prescribed to these patients.</description><identifier>DOI: 10.6084/m9.figshare.9927899</identifier><language>eng</language><publisher>SciELO journals</publisher><subject>FOS: Clinical medicine ; Nephrology and Urology</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>780,1894</link.rule.ids><linktorsrc>$$Uhttps://commons.datacite.org/doi.org/10.6084/m9.figshare.9927899$$EView_record_in_DataCite.org$$FView_record_in_$$GDataCite.org$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Machado, Hanna Karla Andrade Guapyassú</creatorcontrib><creatorcontrib>Martins, Carolina Steller Wagner</creatorcontrib><creatorcontrib>Jorgetti, Vanda</creatorcontrib><creatorcontrib>Rosilene Motta Elias</creatorcontrib><creatorcontrib>Moysés, Rosa Maria Affonso</creatorcontrib><title>Chronic kidney disease is a main confounding factor for 25-vitamin D measurement</title><description>Abstract Background: Current guidelines recommend assessment of 25-vitamin D status in patients with chronic kidney disease (CKD). Although significant differences among assays have been described, the impact of CKD on this variability has never been tested. Methods: We tested the variability between two 25-vitamin D assays in patients with CKD (eGFR < 60 mL/min/1.73m2) who had consecutive 25-vitamin D measurements in 2015 (Assay 1 - Diasorin LIASON 25 TOTAL - D assay®) and 2016 (Assay 2 - Beckman Coulter Unicel Xl 800®). The cohort consisted of 791 adult patients (122 with normal renal function and 669 with CKD - 33, 30, and 37% in stages 3, 4, and 5 on dialysis, respectively). Results: Levels of 25-vitamin D were lower and the prevalence of hypovitaminosis D using assay 1 was higher than using assay 2 in patients with CKD, regardless of similar levels of calcium, phosphate, and parathyroid hormone. As kidney function decreased, the percentage of disagreement between the assays increased. Conclusion: There is a noteworthy variability between assays in patients with CKD such that the diagnosis of hypovitaminosis D is modified. The mechanism behind this result is still unclear and might be due to a possible interference in the analytical process. However, the clinical significance is unquestionable, as the supplementation of vitamin D can be erroneously prescribed to these patients.</description><subject>FOS: Clinical medicine</subject><subject>Nephrology and Urology</subject><fulltext>true</fulltext><rsrctype>dataset</rsrctype><creationdate>2019</creationdate><recordtype>dataset</recordtype><sourceid>PQ8</sourceid><recordid>eNo1j7tuwyAYhVk6VGmfoAsvYAdDDGaM3KsUqRmyox_4SVALrsCplLevq6bD0VnORR8hDx1rJRs266TbEI_1BAVbrbkatL4l-_FUphwd_Yg-44X6WBEq0lgp0AQxUzflMJ2zj_lIA7h5KjQs4n3zHWdIS-KRpqVzLpgwz3fkJsBnxfurr8jh-ekwvja795e3cbtr_PLbCGc72zOpg_KOC_BDb7XzwgboLZNCKqckQ3ReIw9LxXdKD5sgh04oroJYEfE362EGF2c0XyUmKBfTMfOLa5I2_7jmiit-AI95UgY</recordid><startdate>20191002</startdate><enddate>20191002</enddate><creator>Machado, Hanna Karla Andrade Guapyassú</creator><creator>Martins, Carolina Steller Wagner</creator><creator>Jorgetti, Vanda</creator><creator>Rosilene Motta Elias</creator><creator>Moysés, Rosa Maria Affonso</creator><general>SciELO journals</general><scope>DYCCY</scope><scope>PQ8</scope></search><sort><creationdate>20191002</creationdate><title>Chronic kidney disease is a main confounding factor for 25-vitamin D measurement</title><author>Machado, Hanna Karla Andrade Guapyassú ; Martins, Carolina Steller Wagner ; Jorgetti, Vanda ; Rosilene Motta Elias ; Moysés, Rosa Maria Affonso</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-d899-3cb1b5069f7dc23ad85b9cd3bfa5b06367c760eecd9e2fd89d17984f6813727f3</frbrgroupid><rsrctype>datasets</rsrctype><prefilter>datasets</prefilter><language>eng</language><creationdate>2019</creationdate><topic>FOS: Clinical medicine</topic><topic>Nephrology and Urology</topic><toplevel>online_resources</toplevel><creatorcontrib>Machado, Hanna Karla Andrade Guapyassú</creatorcontrib><creatorcontrib>Martins, Carolina Steller Wagner</creatorcontrib><creatorcontrib>Jorgetti, Vanda</creatorcontrib><creatorcontrib>Rosilene Motta Elias</creatorcontrib><creatorcontrib>Moysés, Rosa Maria Affonso</creatorcontrib><collection>DataCite (Open Access)</collection><collection>DataCite</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Machado, Hanna Karla Andrade Guapyassú</au><au>Martins, Carolina Steller Wagner</au><au>Jorgetti, Vanda</au><au>Rosilene Motta Elias</au><au>Moysés, Rosa Maria Affonso</au><format>book</format><genre>unknown</genre><ristype>DATA</ristype><title>Chronic kidney disease is a main confounding factor for 25-vitamin D measurement</title><date>2019-10-02</date><risdate>2019</risdate><abstract>Abstract Background: Current guidelines recommend assessment of 25-vitamin D status in patients with chronic kidney disease (CKD). Although significant differences among assays have been described, the impact of CKD on this variability has never been tested. Methods: We tested the variability between two 25-vitamin D assays in patients with CKD (eGFR < 60 mL/min/1.73m2) who had consecutive 25-vitamin D measurements in 2015 (Assay 1 - Diasorin LIASON 25 TOTAL - D assay®) and 2016 (Assay 2 - Beckman Coulter Unicel Xl 800®). The cohort consisted of 791 adult patients (122 with normal renal function and 669 with CKD - 33, 30, and 37% in stages 3, 4, and 5 on dialysis, respectively). Results: Levels of 25-vitamin D were lower and the prevalence of hypovitaminosis D using assay 1 was higher than using assay 2 in patients with CKD, regardless of similar levels of calcium, phosphate, and parathyroid hormone. As kidney function decreased, the percentage of disagreement between the assays increased. Conclusion: There is a noteworthy variability between assays in patients with CKD such that the diagnosis of hypovitaminosis D is modified. The mechanism behind this result is still unclear and might be due to a possible interference in the analytical process. However, the clinical significance is unquestionable, as the supplementation of vitamin D can be erroneously prescribed to these patients.</abstract><pub>SciELO journals</pub><doi>10.6084/m9.figshare.9927899</doi><oa>free_for_read</oa></addata></record> |
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subjects | FOS: Clinical medicine Nephrology and Urology |
title | Chronic kidney disease is a main confounding factor for 25-vitamin D measurement |
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