SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs

The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. The IC50 values were found to be in the micromolar to submicromolar range. The...

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Hauptverfasser:	Shalaby, Raed, Petzer, Jacobus P., Anél Petzer, Ashraf, Usman M., Ealla Atari, Alasmari, Fawaz, Sivarajan Kumarasamy, Sari, Youssef, Khalil, Ashraf
Format:	Dataset
Sprache:	eng
Schlagworte:	Biochemistry Chemical Sciences not elsewhere classified FOS: Chemical sciences FOS: Health sciences Infectious Diseases
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