Neutrophil-lymphocyte ratio in the early diagnosis of sepsis in an intensive care unit: a case-control study

Neutrophil-lymphocyte ratio in the early diagnosis of sepsis in an intensive care unit: a case-control study

ABSTRACT Objective: To evaluate the neutrophil-lymphocyte ratio as a predictor of sepsis and mortality in patients admitted to an intensive care unit. Methods: Case-control study of adult patients admitted to an intensive care unit. Patients who had sepsis as the reason for admission and who had a p...

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Hauptverfasser: Martins, Eduarda Cristina, Silveira, Lilian Da Fe, Viegas, Karin, Beck, Andrea Diez, Geferson Fioravantti Júnior, Cremonese, Rafael Viegas, Lora, Priscila Schmidt
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FOS: Clinical medicine
Intensive Care
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creator Martins, Eduarda Cristina
Silveira, Lilian Da Fe
Viegas, Karin
Beck, Andrea Diez
Geferson Fioravantti Júnior
Cremonese, Rafael Viegas
Lora, Priscila Schmidt
description ABSTRACT Objective: To evaluate the neutrophil-lymphocyte ratio as a predictor of sepsis and mortality in patients admitted to an intensive care unit. Methods: Case-control study of adult patients admitted to an intensive care unit. Patients who had sepsis as the reason for admission and who had a previous complete blood count examination were included as case patients. The following statistical analyses were performed: ROC curves, binary logistic regression, and Mann-Whitney and Pearson's chi-square tests. p < 0.05 was considered significant. Results: The ROC curve values were 0.62 for neutrophil-lymphocyte ratio, 0.98 for band neutrophils and 0.51 for total leukocytes. The presence of a neutrophil-lymphocyte ratio greater than 5.0, leukocyte count above 12,000mm3/mL and band neutrophil percentage above 10% were risk factors for sepsis; however, only the SAPS 3 and SOFA score were related to patient mortality. Conclusion: The neutrophil-lymphocyte ratio and band neutrophils in combination with other parameters may be markers for the early detection of sepsis in intensive care units.
doi_str_mv 10.6084/m9.figshare.7898576
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Intensive Care
title Neutrophil-lymphocyte ratio in the early diagnosis of sepsis in an intensive care unit: a case-control study
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