Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass
Abstract Purpose: To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation. Methods: A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated w...
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| creator | Machado, Francisco Heine Ferreira Heladio Feitosa De Castro Filho Babadopulos, Rodrigo Feitosa De Albuquerque Lima Hermano Alexandre Lima Rocha Rocha, José Lima De Carvalho Filho, Manoel Odorico De Moraes |
| description | Abstract Purpose: To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation. Methods: A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of 150 mg twice daily (300 mg/day) over a period of 5 consecutive months (GROUP A), and 68 were control patients (GROUP B). The patients were followed-up, and ultrasonography was performed to determine the presence of gallstones at various times during follow-up. Demographic, anthropometric and comorbid indicators were obtained. The data were subjected to normality tests and evaluated using appropriate tests. Results: Patients did not differ in their baseline characteristics. Of the 69 patients who used UDCA, only one patient developed cholelithiasis (1%), whereas 18 controls (26%) formed gallstones (OR = 24.4, p |
| doi_str_mv | 10.6084/m9.figshare.7743128 |
| format | Dataset |
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Methods: A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of 150 mg twice daily (300 mg/day) over a period of 5 consecutive months (GROUP A), and 68 were control patients (GROUP B). The patients were followed-up, and ultrasonography was performed to determine the presence of gallstones at various times during follow-up. Demographic, anthropometric and comorbid indicators were obtained. The data were subjected to normality tests and evaluated using appropriate tests. Results: Patients did not differ in their baseline characteristics. Of the 69 patients who used UDCA, only one patient developed cholelithiasis (1%), whereas 18 controls (26%) formed gallstones (OR = 24.4, p <0.001). Also, other factors were found not to influence the formation of calculi, such as pre-operative or postoperative hepatic steatosis or diabetes (p = 0.759, 0.468, 0.956). Conclusion: The results demonstrated that patients who did not use UDCA showed a 24.4-fold greater probability of developing cholelithiasis.</description><identifier>DOI: 10.6084/m9.figshare.7743128</identifier><language>eng</language><publisher>SciELO journals</publisher><subject>FOS: Clinical medicine ; Surgery</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>780,1894</link.rule.ids><linktorsrc>$$Uhttps://commons.datacite.org/doi.org/10.6084/m9.figshare.7743128$$EView_record_in_DataCite.org$$FView_record_in_$$GDataCite.org$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Machado, Francisco Heine Ferreira</creatorcontrib><creatorcontrib>Heladio Feitosa De Castro Filho</creatorcontrib><creatorcontrib>Babadopulos, Rodrigo Feitosa De Albuquerque Lima</creatorcontrib><creatorcontrib>Hermano Alexandre Lima Rocha</creatorcontrib><creatorcontrib>Rocha, José Lima De Carvalho</creatorcontrib><creatorcontrib>Filho, Manoel Odorico De Moraes</creatorcontrib><title>Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass</title><description>Abstract Purpose: To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation. Methods: A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of 150 mg twice daily (300 mg/day) over a period of 5 consecutive months (GROUP A), and 68 were control patients (GROUP B). The patients were followed-up, and ultrasonography was performed to determine the presence of gallstones at various times during follow-up. Demographic, anthropometric and comorbid indicators were obtained. The data were subjected to normality tests and evaluated using appropriate tests. Results: Patients did not differ in their baseline characteristics. Of the 69 patients who used UDCA, only one patient developed cholelithiasis (1%), whereas 18 controls (26%) formed gallstones (OR = 24.4, p <0.001). Also, other factors were found not to influence the formation of calculi, such as pre-operative or postoperative hepatic steatosis or diabetes (p = 0.759, 0.468, 0.956). Conclusion: The results demonstrated that patients who did not use UDCA showed a 24.4-fold greater probability of developing cholelithiasis.</description><subject>FOS: Clinical medicine</subject><subject>Surgery</subject><fulltext>true</fulltext><rsrctype>dataset</rsrctype><creationdate>2019</creationdate><recordtype>dataset</recordtype><sourceid>PQ8</sourceid><recordid>eNo1kL1uwyAYRVk6VGmfoAsvYBeMbWCsov5JkSpVydAJYfMRU9nGAlLFb1-iptMdztWV7kHogZKyJaJ-nGRp3TEOOkDJec1oJW6RPYToDfjz2g9-dD3WvTPYzTgNgJcAPzAn52fsLT7qcYzJzxAvfNHJZRZxPHXf0CcwOHn86U_nAubiK7djCnmvWxcd4x26sXqMcH_NDdq_PO-3b8Xu4_V9-7QrjJCikECgMiCp4ZVuoba0hU5qS3pGmG1syy3tSMY1k6xiXEqjuWk4rQV0jWjYBrG_WaNTPpJALcFNOqyKEnWRoCap_iWoqwT2C-FmWpE</recordid><startdate>20190220</startdate><enddate>20190220</enddate><creator>Machado, Francisco Heine Ferreira</creator><creator>Heladio Feitosa De Castro Filho</creator><creator>Babadopulos, Rodrigo Feitosa De Albuquerque Lima</creator><creator>Hermano Alexandre Lima Rocha</creator><creator>Rocha, José Lima De Carvalho</creator><creator>Filho, Manoel Odorico De Moraes</creator><general>SciELO journals</general><scope>DYCCY</scope><scope>PQ8</scope></search><sort><creationdate>20190220</creationdate><title>Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass</title><author>Machado, Francisco Heine Ferreira ; Heladio Feitosa De Castro Filho ; Babadopulos, Rodrigo Feitosa De Albuquerque Lima ; Hermano Alexandre Lima Rocha ; Rocha, José Lima De Carvalho ; Filho, Manoel Odorico De Moraes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-d898-9e0e2de91d72a6e4f16eb9af0c303f5f67f1b091d439323799da7d57148eb5853</frbrgroupid><rsrctype>datasets</rsrctype><prefilter>datasets</prefilter><language>eng</language><creationdate>2019</creationdate><topic>FOS: Clinical medicine</topic><topic>Surgery</topic><toplevel>online_resources</toplevel><creatorcontrib>Machado, Francisco Heine Ferreira</creatorcontrib><creatorcontrib>Heladio Feitosa De Castro Filho</creatorcontrib><creatorcontrib>Babadopulos, Rodrigo Feitosa De Albuquerque Lima</creatorcontrib><creatorcontrib>Hermano Alexandre Lima Rocha</creatorcontrib><creatorcontrib>Rocha, José Lima De Carvalho</creatorcontrib><creatorcontrib>Filho, Manoel Odorico De Moraes</creatorcontrib><collection>DataCite (Open Access)</collection><collection>DataCite</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Machado, Francisco Heine Ferreira</au><au>Heladio Feitosa De Castro Filho</au><au>Babadopulos, Rodrigo Feitosa De Albuquerque Lima</au><au>Hermano Alexandre Lima Rocha</au><au>Rocha, José Lima De Carvalho</au><au>Filho, Manoel Odorico De Moraes</au><format>book</format><genre>unknown</genre><ristype>DATA</ristype><title>Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass</title><date>2019-02-20</date><risdate>2019</risdate><abstract>Abstract Purpose: To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation. Methods: A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of 150 mg twice daily (300 mg/day) over a period of 5 consecutive months (GROUP A), and 68 were control patients (GROUP B). The patients were followed-up, and ultrasonography was performed to determine the presence of gallstones at various times during follow-up. Demographic, anthropometric and comorbid indicators were obtained. The data were subjected to normality tests and evaluated using appropriate tests. Results: Patients did not differ in their baseline characteristics. Of the 69 patients who used UDCA, only one patient developed cholelithiasis (1%), whereas 18 controls (26%) formed gallstones (OR = 24.4, p <0.001). Also, other factors were found not to influence the formation of calculi, such as pre-operative or postoperative hepatic steatosis or diabetes (p = 0.759, 0.468, 0.956). Conclusion: The results demonstrated that patients who did not use UDCA showed a 24.4-fold greater probability of developing cholelithiasis.</abstract><pub>SciELO journals</pub><doi>10.6084/m9.figshare.7743128</doi><oa>free_for_read</oa></addata></record> |
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| title | Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass |
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