Circulating early biomarkers of atherogenesis in participants of the Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease

ABSTRACT Objective Our aim was to describe the distribution of selected biomarkers according to age and sex, adjusted for HOMA-IR and adiposity, in a subset of middle-aged individuals of Brazilian Longitudinal Study of Adult Health-ELSA without diabetes mellitus or CVD. Subjects and methods This cro...

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Hauptverfasser: Almeida-Pititto, Bianca De, Ribeiro-Filho, Fernando Flexa, Sandhi Barreto, Duncan, Bruce B., Schmidt, Maria Inês, Lotufo, Paulo A., Bensenor, Isabela M., Ferreira, Sandra R. G.
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creator Almeida-Pititto, Bianca De
Ribeiro-Filho, Fernando Flexa
Sandhi Barreto
Duncan, Bruce B.
Schmidt, Maria Inês
Lotufo, Paulo A.
Bensenor, Isabela M.
Ferreira, Sandra R. G.
description ABSTRACT Objective Our aim was to describe the distribution of selected biomarkers according to age and sex, adjusted for HOMA-IR and adiposity, in a subset of middle-aged individuals of Brazilian Longitudinal Study of Adult Health-ELSA without diabetes mellitus or CVD. Subjects and methods This cross-sectional study was conducted in 998 participants of the ELSA-Brasil without diabetes and/or cardiovascular disease. In addition to the traditional risk factors, several biomarkers concentrations were compared according to sex, age groups (35-44; 45-54 yrs) and HOMA-IR tertiles. Linear regression was used to examine independent associations of sex and age with selected novel biomarkers, adjusted for body adiposity and HOMA-IR. Results Fifty-five percent were women. Men had higher mean values of body mass index, waist circumference, blood pressure, plasma glucose, HOMA-IR, worse lipid profile and higher E-selectin and lower leptin concentrations than women; while women had higher levels of HDL-cholesterol and leptin than men. Mean values of waist circumference, systolic BP, plasma glucose and apolipoprotein B (Apo B) increased with age in both sexes. Leptin and E-selectin concentrations increased across HOMA-IR tertiles. Independent associations of Apo B with age were found only in male sex, while of leptin with body mass index and HOMA-IR, and of E-selectin with HOMA-IR in both sexes. Conclusions In conclusion, our data indicate age, sex, adiposity and, consequently, insulin resistance, influence circulating levels of Apo B, leptin and E-selectin, suggesting that those aspects should be taken into consideration when assessing these parameters for research or clinical purposes in individuals at relatively low cardiometabolic risk.
doi_str_mv 10.6084/m9.figshare.7511159
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G.</creator><creatorcontrib>Almeida-Pititto, Bianca De ; Ribeiro-Filho, Fernando Flexa ; Sandhi Barreto ; Duncan, Bruce B. ; Schmidt, Maria Inês ; Lotufo, Paulo A. ; Bensenor, Isabela M. ; Ferreira, Sandra R. G.</creatorcontrib><description>ABSTRACT Objective Our aim was to describe the distribution of selected biomarkers according to age and sex, adjusted for HOMA-IR and adiposity, in a subset of middle-aged individuals of Brazilian Longitudinal Study of Adult Health-ELSA without diabetes mellitus or CVD. Subjects and methods This cross-sectional study was conducted in 998 participants of the ELSA-Brasil without diabetes and/or cardiovascular disease. In addition to the traditional risk factors, several biomarkers concentrations were compared according to sex, age groups (35-44; 45-54 yrs) and HOMA-IR tertiles. Linear regression was used to examine independent associations of sex and age with selected novel biomarkers, adjusted for body adiposity and HOMA-IR. Results Fifty-five percent were women. Men had higher mean values of body mass index, waist circumference, blood pressure, plasma glucose, HOMA-IR, worse lipid profile and higher E-selectin and lower leptin concentrations than women; while women had higher levels of HDL-cholesterol and leptin than men. Mean values of waist circumference, systolic BP, plasma glucose and apolipoprotein B (Apo B) increased with age in both sexes. Leptin and E-selectin concentrations increased across HOMA-IR tertiles. Independent associations of Apo B with age were found only in male sex, while of leptin with body mass index and HOMA-IR, and of E-selectin with HOMA-IR in both sexes. Conclusions In conclusion, our data indicate age, sex, adiposity and, consequently, insulin resistance, influence circulating levels of Apo B, leptin and E-selectin, suggesting that those aspects should be taken into consideration when assessing these parameters for research or clinical purposes in individuals at relatively low cardiometabolic risk.</description><identifier>DOI: 10.6084/m9.figshare.7511159</identifier><language>eng</language><publisher>SciELO journals</publisher><subject>Endocrinology ; FOS: Clinical medicine ; Medicine</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>781,1895</link.rule.ids><linktorsrc>$$Uhttps://commons.datacite.org/doi.org/10.6084/m9.figshare.7511159$$EView_record_in_DataCite.org$$FView_record_in_$$GDataCite.org$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Almeida-Pititto, Bianca De</creatorcontrib><creatorcontrib>Ribeiro-Filho, Fernando Flexa</creatorcontrib><creatorcontrib>Sandhi Barreto</creatorcontrib><creatorcontrib>Duncan, Bruce B.</creatorcontrib><creatorcontrib>Schmidt, Maria Inês</creatorcontrib><creatorcontrib>Lotufo, Paulo A.</creatorcontrib><creatorcontrib>Bensenor, Isabela M.</creatorcontrib><creatorcontrib>Ferreira, Sandra R. 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Men had higher mean values of body mass index, waist circumference, blood pressure, plasma glucose, HOMA-IR, worse lipid profile and higher E-selectin and lower leptin concentrations than women; while women had higher levels of HDL-cholesterol and leptin than men. Mean values of waist circumference, systolic BP, plasma glucose and apolipoprotein B (Apo B) increased with age in both sexes. Leptin and E-selectin concentrations increased across HOMA-IR tertiles. Independent associations of Apo B with age were found only in male sex, while of leptin with body mass index and HOMA-IR, and of E-selectin with HOMA-IR in both sexes. Conclusions In conclusion, our data indicate age, sex, adiposity and, consequently, insulin resistance, influence circulating levels of Apo B, leptin and E-selectin, suggesting that those aspects should be taken into consideration when assessing these parameters for research or clinical purposes in individuals at relatively low cardiometabolic risk.</description><subject>Endocrinology</subject><subject>FOS: Clinical medicine</subject><subject>Medicine</subject><fulltext>true</fulltext><rsrctype>dataset</rsrctype><creationdate>2018</creationdate><recordtype>dataset</recordtype><sourceid>PQ8</sourceid><recordid>eNo1kLFOwzAURbMwoMIXsHiEISWuE8ceS1UoUiSGdo9e7ZfkCTepbAfUv-FTSWmZ3pXO1dXTSZIHns1lpvLng5431IYOPM7LgnNe6NvkZ0XejA4i9S1D8O7E9jQcwH-iD2xoGMQO_dBij4ECo54dwUcydIQ-_hUmzqqhbymOlnpwbDuF05ks7egi2yC42LHHdbVdpi8eArkn9k2xG8bILMEeI05DnhnwloYvCOd__IQCQsC75KYBF_D-emfJ7nW9W23S6uPtfbWsUqu0Tm2p9wXYnBuDRqrcWKkFz3kjOGZcKi7KouQ2g6mksFSqLBZKlqqRsrHFQohZIi6zFiIYilgfPU0aTjXP6rO--qDrf331VZ_4BaPobzk</recordid><startdate>20181226</startdate><enddate>20181226</enddate><creator>Almeida-Pititto, Bianca De</creator><creator>Ribeiro-Filho, Fernando Flexa</creator><creator>Sandhi Barreto</creator><creator>Duncan, Bruce B.</creator><creator>Schmidt, Maria Inês</creator><creator>Lotufo, Paulo A.</creator><creator>Bensenor, Isabela M.</creator><creator>Ferreira, Sandra R. 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G.</creatorcontrib><collection>DataCite (Open Access)</collection><collection>DataCite</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Almeida-Pititto, Bianca De</au><au>Ribeiro-Filho, Fernando Flexa</au><au>Sandhi Barreto</au><au>Duncan, Bruce B.</au><au>Schmidt, Maria Inês</au><au>Lotufo, Paulo A.</au><au>Bensenor, Isabela M.</au><au>Ferreira, Sandra R. G.</au><format>book</format><genre>unknown</genre><ristype>DATA</ristype><title>Circulating early biomarkers of atherogenesis in participants of the Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease</title><date>2018-12-26</date><risdate>2018</risdate><abstract>ABSTRACT Objective Our aim was to describe the distribution of selected biomarkers according to age and sex, adjusted for HOMA-IR and adiposity, in a subset of middle-aged individuals of Brazilian Longitudinal Study of Adult Health-ELSA without diabetes mellitus or CVD. Subjects and methods This cross-sectional study was conducted in 998 participants of the ELSA-Brasil without diabetes and/or cardiovascular disease. In addition to the traditional risk factors, several biomarkers concentrations were compared according to sex, age groups (35-44; 45-54 yrs) and HOMA-IR tertiles. Linear regression was used to examine independent associations of sex and age with selected novel biomarkers, adjusted for body adiposity and HOMA-IR. Results Fifty-five percent were women. Men had higher mean values of body mass index, waist circumference, blood pressure, plasma glucose, HOMA-IR, worse lipid profile and higher E-selectin and lower leptin concentrations than women; while women had higher levels of HDL-cholesterol and leptin than men. Mean values of waist circumference, systolic BP, plasma glucose and apolipoprotein B (Apo B) increased with age in both sexes. Leptin and E-selectin concentrations increased across HOMA-IR tertiles. Independent associations of Apo B with age were found only in male sex, while of leptin with body mass index and HOMA-IR, and of E-selectin with HOMA-IR in both sexes. Conclusions In conclusion, our data indicate age, sex, adiposity and, consequently, insulin resistance, influence circulating levels of Apo B, leptin and E-selectin, suggesting that those aspects should be taken into consideration when assessing these parameters for research or clinical purposes in individuals at relatively low cardiometabolic risk.</abstract><pub>SciELO journals</pub><doi>10.6084/m9.figshare.7511159</doi><oa>free_for_read</oa></addata></record>
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subjects Endocrinology
FOS: Clinical medicine
Medicine
title Circulating early biomarkers of atherogenesis in participants of the Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease
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