Glycemic control and the production of cytokines in diabetic patients with chronic periodontal disease

Glycemic control and the production of cytokines in diabetic patients with chronic periodontal disease

ABSTRACT Objective: To evaluate the association of glycemic control and cytokine production in type 2 diabetic subjects with chronic periodontitis Methods: Gingival biopsies were performed in 40 patients, divided into four groups: systemically healthy subjects without periodontal disease (S); system...

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Hauptverfasser: FRANCO, Mayra Moura, MORAES, Mariana Mader Miranda, DUARTE, Poliana Mendes, NAPIMOGA, Marcelo Henrique, BENATTI, Bruno Braga
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Dentistry not elsewhere classified
FOS: Clinical medicine
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creator FRANCO, Mayra Moura
MORAES, Mariana Mader Miranda
DUARTE, Poliana Mendes
NAPIMOGA, Marcelo Henrique
BENATTI, Bruno Braga
description ABSTRACT Objective: To evaluate the association of glycemic control and cytokine production in type 2 diabetic subjects with chronic periodontitis Methods: Gingival biopsies were performed in 40 patients, divided into four groups: systemically healthy subjects without periodontal disease (S); systemically healthy patients with chronic periodontitis (P); patients with well-controlled type 2 diabetes mellitus (DM) with chronic periodontitis (C); poorly controlled type 2 diabetes mellitus with chronic periodontitis (D). The production of interleukin (IL) -4, -6, -10, -17 and interferon (IFN) -γ was quantified by ELISA. Results: The production of IL-4, IL-10, IL-17 and INF-γ was higher on group D when compared to other groups (p
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The production of interleukin (IL) -4, -6, -10, -17 and interferon (IFN) -γ was quantified by ELISA. Results: The production of IL-4, IL-10, IL-17 and INF-γ was higher on group D when compared to other groups (p &lt;0.05), which in turn were similar (p ≥0.05). In addition, there was no difference in the production of IL-6 in any of the evaluated groups (p≥0.05). Conclusion: Were observed significantly elevated levels of pro-inflammatory and anti-inflammatory cytokines in patients with poorly controlled type 2 diabetes and chronic periodontitis, demonstrating that glycemic control may be associated to the immune inflammatory response of sites with chronic periodontitis.</description><identifier>DOI: 10.6084/m9.figshare.7507589</identifier><language>eng</language><publisher>SciELO journals</publisher><subject>Dentistry not elsewhere classified ; FOS: Clinical medicine</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>780,1894</link.rule.ids><linktorsrc>$$Uhttps://commons.datacite.org/doi.org/10.6084/m9.figshare.7507589$$EView_record_in_DataCite.org$$FView_record_in_$$GDataCite.org$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FRANCO, Mayra Moura</creatorcontrib><creatorcontrib>MORAES, Mariana Mader Miranda</creatorcontrib><creatorcontrib>DUARTE, Poliana Mendes</creatorcontrib><creatorcontrib>NAPIMOGA, Marcelo Henrique</creatorcontrib><creatorcontrib>BENATTI, Bruno Braga</creatorcontrib><title>Glycemic control and the production of cytokines in diabetic patients with chronic periodontal disease</title><description>ABSTRACT Objective: To evaluate the association of glycemic control and cytokine production in type 2 diabetic subjects with chronic periodontitis Methods: Gingival biopsies were performed in 40 patients, divided into four groups: systemically healthy subjects without periodontal disease (S); systemically healthy patients with chronic periodontitis (P); patients with well-controlled type 2 diabetes mellitus (DM) with chronic periodontitis (C); poorly controlled type 2 diabetes mellitus with chronic periodontitis (D). The production of interleukin (IL) -4, -6, -10, -17 and interferon (IFN) -γ was quantified by ELISA. Results: The production of IL-4, IL-10, IL-17 and INF-γ was higher on group D when compared to other groups (p &lt;0.05), which in turn were similar (p ≥0.05). In addition, there was no difference in the production of IL-6 in any of the evaluated groups (p≥0.05). 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The production of interleukin (IL) -4, -6, -10, -17 and interferon (IFN) -γ was quantified by ELISA. Results: The production of IL-4, IL-10, IL-17 and INF-γ was higher on group D when compared to other groups (p &lt;0.05), which in turn were similar (p ≥0.05). In addition, there was no difference in the production of IL-6 in any of the evaluated groups (p≥0.05). Conclusion: Were observed significantly elevated levels of pro-inflammatory and anti-inflammatory cytokines in patients with poorly controlled type 2 diabetes and chronic periodontitis, demonstrating that glycemic control may be associated to the immune inflammatory response of sites with chronic periodontitis.</abstract><pub>SciELO journals</pub><doi>10.6084/m9.figshare.7507589</doi><oa>free_for_read</oa></addata></record>
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subjects Dentistry not elsewhere classified
FOS: Clinical medicine
title Glycemic control and the production of cytokines in diabetic patients with chronic periodontal disease
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