A complex pattern of chemokine receptor expression is seen in osteosarcoma-0

Copyright information:Taken from "A complex pattern of chemokine receptor expression is seen in osteosarcoma"http://www.biomedcentral.com/1471-2407/8/23BMC Cancer 2008;8():23-23.Published online 24 Jan 2008PMCID:PMC2257957.osteosarcoma biopsy samples with each circle representing the value of a single sample. indicate the mRNA expression of the osteoblastoma. Median values of at least three independent RNA preparations are represented by for primary MSC, undifferentiated () and differentiated osteoblasts (). The grey field indicates borderline detectable expression values, defined as CT values between 38 and 40 cycles. All values below are rated as negative values (nd = not detectable). The represents expression levels normalized vs. rRNA. On the x-axis the chemokine receptors are indicated. CCR1, CCR2, CCR5, CCR7, CXCR4, CXCR5 and CX3CR1 are expressed in all of the tested samples. CCR4 is expressed in 21/22 tumors. CXCR3 is only detectable in a fraction of the tested samples and CCR10 is either borderline or not detectable. The overall receptor expression is higher in the tumor than in the bone precursors. The benign bone tumor (osteoblastoma) demonstrates expression values that are close to those of the sarcoma tissue.