Immunostaining for iNOS in liver from: A, healthy control group (CO); B, untreated cirrhotic group (CI); C, cirrhotic animals treated with IGF-I for three weeks

Copyright information:Taken from "Antioxidant effects of insulin-like growth factor-I (IGF-I) in rats with advanced liver cirrhosis"BMC Gastroenterology 2005;5():7-7.Published online 3 Mar 2005PMCID:PMC555751.Copyright © 2005 García-Fernández et al; licensee BioMed Central Ltd. An increased iNOS immunoreactivity was observed in hepatocytes from CI group, compared to controls and CI+IGF groups. These two pictures (B and C) correspond to two animals from each cirrhotic group that presented the most severe cirrhosis. Although in this section (C, CI+IGF) from a series with decompensated cirrhosis can be observed thick collagen septa, it is also clear the hepatoprotective effect of the IGF-I-therapy versus untreated cirrhotic group (B).