Effect of protein kinase C inhibitor bisindolylmaleimide I (BIM) on morphine modulation of HGABA release

Effect of protein kinase C inhibitor bisindolylmaleimide I (BIM) on morphine modulation of HGABA release

Copyright information:Taken from "Opioid modulation of GABA release in the rat inferior colliculus"BMC Neuroscience 2004;5():31-31.Published online 7 Sep 2004PMCID:PMC517931.Copyright © 2004 Tongjaroenbungam et al; licensee BioMed Central Ltd. BIM is reported to reduce receptor desensitiza...

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Hauptverfasser: Walaiporn Tongjaroenbungam, Nopporn Jongkamonwiwat, Cunningham, Joanna, Pansiri Phansuwan-Pujito, Dodson, Hilary C, Forge, Andrew, Piyarat Govitrapong, Casalotti, Stefano O
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creator Walaiporn Tongjaroenbungam
Nopporn Jongkamonwiwat
Cunningham, Joanna
Pansiri Phansuwan-Pujito
Dodson, Hilary C
Forge, Andrew
Piyarat Govitrapong
Casalotti, Stefano O
description Copyright information:Taken from "Opioid modulation of GABA release in the rat inferior colliculus"BMC Neuroscience 2004;5():31-31.Published online 7 Sep 2004PMCID:PMC517931.Copyright © 2004 Tongjaroenbungam et al; licensee BioMed Central Ltd. BIM is reported to reduce receptor desensitization and was used here to test whether morphine would elicit a bigger effect on [H]GABA release in the presence of BIM. BIM is initially dissolved in DMSO whose effect on [H]GABA release was also tested. BIM (1 μM) was present throughout the perfusion where indicated. Data represent averages ± SEM. Labels on the x-axis indicate concentration of morphine present during S2. The data show that morphine caused a reduction of [H]GABA release as shown in Figure 2 but there was no statistical difference between experiments with or without BIM (One way ANOVA).
doi_str_mv 10.6084/m9.figshare.32401
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BIM is reported to reduce receptor desensitization and was used here to test whether morphine would elicit a bigger effect on [H]GABA release in the presence of BIM. BIM is initially dissolved in DMSO whose effect on [H]GABA release was also tested. BIM (1 μM) was present throughout the perfusion where indicated. Data represent averages ± SEM. Labels on the x-axis indicate concentration of morphine present during S2. 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title Effect of protein kinase C inhibitor bisindolylmaleimide I (BIM) on morphine modulation of HGABA release
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