We assess COG category recovery for the four individual methods, the combination of the four methods, and TextLinks

Copyright information:Taken from "Prolinks: a database of protein functional linkages derived from coevolution"Genome Biology 2004;5(5):R35-R35.Published online 16 Apr 2004PMCID:PMC416471.Copyright © 2004 Bowers et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. We assign a confidence measure to the likelihood that a pair of proteins is acting within the same COG pathway, reflecting the number of COG-annotated pairs that lie within the same pathway relative to the total number of annotated pairs. The COG confidence metric is used in the network-graphing function of the Proteome Navigator to select inferred protein linkages with uniform confidence. protein pairs displayed in this figure have a COG pathway confidence recovery (cumulative accuracy) of greater than 0.4, with the exception of the TextLinks pairs. The receiver operator characteristic (ROC) curve shows the performance of the rank-ordered list of all interactions predicted from genomic inference (solid line) compared with the random selection of protein pairs (dashed line).