Additional file 5 of CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
Additional file 5: Figure S5. Deletion of Cpt1a in AgRP neurons upregulates Cpt1a expression in the liver. a Representative hematoxylin and eosin (H&E) staining of the livers of male and female mice. Scale bar, 50 µm (magnification 20×). b and d Liver weight of female (b, n = 6–8) and male mice...
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| creator | Zagmutt, Sebastián Mera, Paula González-García, Ismael Ibeas, Kevin Romero, María del Mar Obri, Arnaud Martin, Beatriz Esteve-Codina, Anna Soler-Vázquez, M. Carmen Bastias-Pérez, Marianela Cañes, Laia Augé, Elisabeth Pelegri, Carme Vilaplana, Jordi Ariza, Xavier García, Jordi Martinez-González, José Casals, Núria López, Miguel Palmiter, Richard Sanz, Elisenda Quintana, Albert Herrero, Laura Serra, Dolors |
| description | Additional file 5: Figure S5. Deletion of Cpt1a in AgRP neurons upregulates Cpt1a expression in the liver. a Representative hematoxylin and eosin (H&E) staining of the livers of male and female mice. Scale bar, 50 µm (magnification 20×). b and d Liver weight of female (b, n = 6–8) and male mice (d, n = 6–8). (c and e) Analysis by qRT-PCR of Cpt1a, Cd36, Ucp2, Hmgcs2, Pepck and G6pc mRNA levels in female (c, n = 8) and male mice (e, n = 9–8). f Representative H&E staining of the pancreas and testes from male mice (upper panel) and the pancreas and ovaries from female mice (lower panel). g Plasma level of 17β-estradiol in female mice (n = 8–8) and h testosterone level in male mice (n = 9–10). Scale bar, 50 µm (magnification 20×). Data are expressed as the mean ± SEM. In b–e, * p |
| doi_str_mv | 10.6084/m9.figshare.26577731 |
| format | Image |
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Carmen ; Bastias-Pérez, Marianela ; Cañes, Laia ; Augé, Elisabeth ; Pelegri, Carme ; Vilaplana, Jordi ; Ariza, Xavier ; García, Jordi ; Martinez-González, José ; Casals, Núria ; López, Miguel ; Palmiter, Richard ; Sanz, Elisenda ; Quintana, Albert ; Herrero, Laura ; Serra, Dolors</creator><creatorcontrib>Zagmutt, Sebastián ; Mera, Paula ; González-García, Ismael ; Ibeas, Kevin ; Romero, María del Mar ; Obri, Arnaud ; Martin, Beatriz ; Esteve-Codina, Anna ; Soler-Vázquez, M. Carmen ; Bastias-Pérez, Marianela ; Cañes, Laia ; Augé, Elisabeth ; Pelegri, Carme ; Vilaplana, Jordi ; Ariza, Xavier ; García, Jordi ; Martinez-González, José ; Casals, Núria ; López, Miguel ; Palmiter, Richard ; Sanz, Elisenda ; Quintana, Albert ; Herrero, Laura ; Serra, Dolors</creatorcontrib><description>Additional file 5: Figure S5. Deletion of Cpt1a in AgRP neurons upregulates Cpt1a expression in the liver. a Representative hematoxylin and eosin (H&E) staining of the livers of male and female mice. Scale bar, 50 µm (magnification 20×). b and d Liver weight of female (b, n = 6–8) and male mice (d, n = 6–8). (c and e) Analysis by qRT-PCR of Cpt1a, Cd36, Ucp2, Hmgcs2, Pepck and G6pc mRNA levels in female (c, n = 8) and male mice (e, n = 9–8). f Representative H&E staining of the pancreas and testes from male mice (upper panel) and the pancreas and ovaries from female mice (lower panel). g Plasma level of 17β-estradiol in female mice (n = 8–8) and h testosterone level in male mice (n = 9–10). Scale bar, 50 µm (magnification 20×). Data are expressed as the mean ± SEM. 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Deletion of Cpt1a in AgRP neurons upregulates Cpt1a expression in the liver. a Representative hematoxylin and eosin (H&E) staining of the livers of male and female mice. Scale bar, 50 µm (magnification 20×). b and d Liver weight of female (b, n = 6–8) and male mice (d, n = 6–8). (c and e) Analysis by qRT-PCR of Cpt1a, Cd36, Ucp2, Hmgcs2, Pepck and G6pc mRNA levels in female (c, n = 8) and male mice (e, n = 9–8). f Representative H&E staining of the pancreas and testes from male mice (upper panel) and the pancreas and ovaries from female mice (lower panel). g Plasma level of 17β-estradiol in female mice (n = 8–8) and h testosterone level in male mice (n = 9–10). Scale bar, 50 µm (magnification 20×). Data are expressed as the mean ± SEM. 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| title | Additional file 5 of CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst |
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