Evaluation of limited-sampling strategies to calculate AUC(0-24) and the role of CYP3A5 in Chilean pediatric kidney recipients using extended-release Tacrolimus

Background: Kidney transplantation (KTx) requires immunosuppressive drugs such as Tacrolimus (TAC) which is mainly metabolized by CYP3A5. TAC is routinely monitored by trough levels (C0) although it has not shown to be a reliable marker. The area-under-curve (AUC) is a more realistic measure of drug...

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Hauptverfasser:	Galvez, Carla, Boza, Pía, González, Mariluz, Hormazabal, Catalina, Encina, Marlene, Azócar, Manuel, Castañeda, Luis, Rojo, Angélica, Ceballos, María Luisa, Krall, Paola
Format:	Dataset
Sprache:	eng
Schlagworte:	FOS: Medical biotechnology Pharmacogenomics
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