Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies

Synapses represent an important target of Alzheimer disease (AD), and alterations of their excitability are among the earliest changes associated with AD development. Synaptic activation has been shown to be protective in models of AD, and deep brain stimulation (DBS), a surgical strategy that modul...

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Hauptverfasser:	Akwa, Yvette, Di Malta, Chiara, Zallo, Fátima, Gondard, Elise, Lunati, Adele, Diaz-de-Grenu, Lara Z., Zampelli, Angela, Boiret, Anne, Santamaria, Sara, Martinez-Preciado, Maialen, Cortese, Katia, Kordower, Jeffrey H., Matute, Carlos, Lozano, Andres M., Capetillo-Zarate, Estibaliz, Vaccari, Thomas, Settembre, Carmine, Baulieu, Etienne E., Tampellini, Davide
Format:	Dataset
Sprache:	eng
Schlagworte:	Biochemistry Biological Sciences not elsewhere classified Biotechnology Cell Biology FOS: Biological sciences FOS: Clinical medicine FOS: Health sciences Immunology Marine Biology Mental Health Molecular Biology Neuroscience Physiology Science Policy
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