Additional file 3 of CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease
Additional file 3: Supplemental Fig. 3. Top biological processes and signaling pathways altered in 6 month-old 5xFAD;Cx3cr1-/- mice when compared to 5xFAD;Cx3cr1+/+ mice. RNA extracts from cortical lysates from n = 6 animals (3 females, 3 males) were used for Nanostring based transcriptional profili...
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| creator | Puntambekar, Shweta S. Moutinho, Miguel Lin, Peter Bor-Chian Jadhav, Vaishnavi Tumbleson-Brink, Danika Balaji, Ananya Benito, Martin Alvarado Xu, Guixiang Oblak, Adrian Lasagna-Reeves, Cristian A. Landreth, Gary E. Lamb, Bruce T. |
| description | Additional file 3: Supplemental Fig. 3. Top biological processes and signaling pathways altered in 6 month-old 5xFAD;Cx3cr1-/- mice when compared to 5xFAD;Cx3cr1+/+ mice. RNA extracts from cortical lysates from n = 6 animals (3 females, 3 males) were used for Nanostring based transcriptional profiling. (A) Gene ontology (GO) analyses showing the top 11 altered biological pathways in female vs. male 5xFAD;Cx3cr1-/- mice with respect to sex-matched 5xFAD;Cx3cr1+/+ mice. Venn diagram highlighting (B) common biological pathways using GO analysis and (C) common neuropathology signaling pathways and cellular processes using KEGG analysis in male and female 5xFAD;Cx3cr1-/- mice as compared to 5xFAD;Cx3cr1+/+ mice. GO and KEGG analysis done on significant differentially expressed genes (DEGs), which were calculated using the Benjamini-Hochberg test in the Nanostring nCounter Analysis Software. |
| doi_str_mv | 10.6084/m9.figshare.20175588 |
| format | Image |
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Top biological processes and signaling pathways altered in 6 month-old 5xFAD;Cx3cr1-/- mice when compared to 5xFAD;Cx3cr1+/+ mice. RNA extracts from cortical lysates from n = 6 animals (3 females, 3 males) were used for Nanostring based transcriptional profiling. (A) Gene ontology (GO) analyses showing the top 11 altered biological pathways in female vs. male 5xFAD;Cx3cr1-/- mice with respect to sex-matched 5xFAD;Cx3cr1+/+ mice. Venn diagram highlighting (B) common biological pathways using GO analysis and (C) common neuropathology signaling pathways and cellular processes using KEGG analysis in male and female 5xFAD;Cx3cr1-/- mice as compared to 5xFAD;Cx3cr1+/+ mice. 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Top biological processes and signaling pathways altered in 6 month-old 5xFAD;Cx3cr1-/- mice when compared to 5xFAD;Cx3cr1+/+ mice. RNA extracts from cortical lysates from n = 6 animals (3 females, 3 males) were used for Nanostring based transcriptional profiling. (A) Gene ontology (GO) analyses showing the top 11 altered biological pathways in female vs. male 5xFAD;Cx3cr1-/- mice with respect to sex-matched 5xFAD;Cx3cr1+/+ mice. Venn diagram highlighting (B) common biological pathways using GO analysis and (C) common neuropathology signaling pathways and cellular processes using KEGG analysis in male and female 5xFAD;Cx3cr1-/- mice as compared to 5xFAD;Cx3cr1+/+ mice. GO and KEGG analysis done on significant differentially expressed genes (DEGs), which were calculated using the Benjamini-Hochberg test in the Nanostring nCounter Analysis Software.</abstract><pub>figshare</pub><doi>10.6084/m9.figshare.20175588</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Cell Biology Computational Biology FOS: Clinical medicine FOS: Health sciences Immunology Infectious Diseases Medicine Mental Health Neuroscience |
| title | Additional file 3 of CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease |
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