Relative selectivity of SP-CTA for NK1, NK2 and NK3 receptors

Relative selectivity of SP-CTA for NK1, NK2 and NK3 receptors

Copyright information:Taken from "Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin"http://www.biomedcentral.com/1471-2202/8/30BMC Neuroscience 2007;8():30-30.Published online 10 May 2007PMCID:PMC1878491. Concentration response relationships...

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Hauptverfasser: Caudle, Robert M, Mannes, Andrew J, Keller, Jason, Perez, Federico M, Suckow, Shelby K, Neubert, John K
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creator Caudle, Robert M
Mannes, Andrew J
Keller, Jason
Perez, Federico M
Suckow, Shelby K
Neubert, John K
description Copyright information:Taken from "Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin"http://www.biomedcentral.com/1471-2202/8/30BMC Neuroscience 2007;8():30-30.Published online 10 May 2007PMCID:PMC1878491. Concentration response relationships for SP-CTA on the stimulation of cAMP production were performed on CHO cells transiently transfected with NK1 or NK2 receptors. Non-transfected CHO cells were either not exposed to SP-CTA (Ctrl) or treated with 10 ng/ml SP-CTA (Ctrl 10). CHO cells stably transfected with NK3 receptors were treated with a single concentration of 10 ng/ml SP-CTA. (Two way ANOVA of NK1 versus NK2, F = 1.7, df = 1, p = 0.20: Dose, F = 54.61, df = 6, p < 0.0001). Asterisks indicate p < 0.01 (one way ANOVA followed by Dunnett's post hoc test, F = 56.15, df = 83) when compared to control cells not treated with SP-CTA.
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Concentration response relationships for SP-CTA on the stimulation of cAMP production were performed on CHO cells transiently transfected with NK1 or NK2 receptors. Non-transfected CHO cells were either not exposed to SP-CTA (Ctrl) or treated with 10 ng/ml SP-CTA (Ctrl 10). CHO cells stably transfected with NK3 receptors were treated with a single concentration of 10 ng/ml SP-CTA. (Two way ANOVA of NK1 versus NK2, F = 1.7, df = 1, p = 0.20: Dose, F = 54.61, df = 6, p &lt; 0.0001). 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title Relative selectivity of SP-CTA for NK1, NK2 and NK3 receptors
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