Additional file 1 of RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma
Additional file 1: Figure S1. Female Balb/c mice were senitised with house dust mite (HDM) in complete Freunds adjuvant intraperitoneally on days 0 and 1 and subsequently challenged intratracheally with saline (N = 6) or HDM in saline (N = 8) on days 14 and 15. BIX119 was dosed twice daily on days 1...
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| creator | Lamb, David De Sousa, Dorothy Quast, Karsten Fundel-Clemens, Katrin Erjefält, Jonas S. Sandén, Caroline Hoffmann, Hans Jürgen Kästle, Marc Schmid, Ramona Menden, Kevin Delic, Denis |
| description | Additional file 1: Figure S1. Female Balb/c mice were senitised with house dust mite (HDM) in complete Freunds adjuvant intraperitoneally on days 0 and 1 and subsequently challenged intratracheally with saline (N = 6) or HDM in saline (N = 8) on days 14 and 15. BIX119 was dosed twice daily on days 14 and 15 by oral gavage. Mice were sacrificed on day 16 and airway eosinophils (a), IL-4 (b) and IL-5 (c) were measured. |
| doi_str_mv | 10.6084/m9.figshare.14651103 |
| format | Video |
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| subjects | FOS: Clinical medicine Immunology |
| title | Additional file 1 of RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma |
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