Additional file 1 of RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma

Additional file 1 of RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma

Additional file 1: Figure S1. Female Balb/c mice were senitised with house dust mite (HDM) in complete Freunds adjuvant intraperitoneally on days 0 and 1 and subsequently challenged intratracheally with saline (N = 6) or HDM in saline (N = 8) on days 14 and 15. BIX119 was dosed twice daily on days 1...

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Bibliographische Detailangaben
Hauptverfasser: Lamb, David, De Sousa, Dorothy, Quast, Karsten, Fundel-Clemens, Katrin, Erjefält, Jonas S., Sandén, Caroline, Hoffmann, Hans Jürgen, Kästle, Marc, Schmid, Ramona, Menden, Kevin, Delic, Denis
Format: Video
Sprache:eng
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FOS: Clinical medicine
Immunology
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Zusammenfassung:Additional file 1: Figure S1. Female Balb/c mice were senitised with house dust mite (HDM) in complete Freunds adjuvant intraperitoneally on days 0 and 1 and subsequently challenged intratracheally with saline (N = 6) or HDM in saline (N = 8) on days 14 and 15. BIX119 was dosed twice daily on days 14 and 15 by oral gavage. Mice were sacrificed on day 16 and airway eosinophils (a), IL-4 (b) and IL-5 (c) were measured.
DOI:10.6084/m9.figshare.14651103