Evaluation of CD109, PCP4 and SEMA3D genes for their association with Ovine Johne’s disease in Turkish sheep
Johne’s disease is a chronic, contagious, zoonotic disease that affects numerous species including livestock and sometimes humans. The disease is globally distributed in sheep populations and caused by Mycobacterium avium Subsp. paratuberculosis (MAP). A previous genome-wide association study identi...
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| creator | Yaman, Yalçın Aymaz, Ramazan Keleş, Murat Bay, Veysel Hatipoğlu, Ecem Kaptan, Cüneyt Başkurt, Atilla Yilmaz, Onur Heaton, Michael P. |
| description | Johne’s disease is a chronic, contagious, zoonotic disease that affects numerous species including livestock and sometimes humans. The disease is globally distributed in sheep populations and caused by Mycobacterium avium Subsp. paratuberculosis (MAP). A previous genome-wide association study identified single nucleotide polymorphism (SNP) markers associated with OJD serostatus in CD109, PCP4, and SEMA3D genes. Our aim was to evaluate the same markers for association with OJD seroprevalence in Turkish sheep in a retrospective matched case-control study. The serological status for OJD in 1801 sheep was determined for four native and four composite breeds from three research flocks. One hundred eleven matched case-control pairs were constructed according to breed type and age from 1750 comingled ewes reared in the same environment. A Single Nucleotide Primer Extension (SNuPE) assay was designed to genotype PCP4-Intron 1, PCP4-3’UTR, SEMA3D, CD109-intron 2 and CD109-intron 8 markers and a McNemar’s test was performed on the matched pairs. An association with these five markers was not detected with the OJD serostatus in Turkish sheep (power of detection, 0.95; odds ratio >3; McNemar’s p |
| doi_str_mv | 10.6084/m9.figshare.14068549 |
| format | Dataset |
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The disease is globally distributed in sheep populations and caused by Mycobacterium avium Subsp. paratuberculosis (MAP). A previous genome-wide association study identified single nucleotide polymorphism (SNP) markers associated with OJD serostatus in CD109, PCP4, and SEMA3D genes. Our aim was to evaluate the same markers for association with OJD seroprevalence in Turkish sheep in a retrospective matched case-control study. The serological status for OJD in 1801 sheep was determined for four native and four composite breeds from three research flocks. One hundred eleven matched case-control pairs were constructed according to breed type and age from 1750 comingled ewes reared in the same environment. A Single Nucleotide Primer Extension (SNuPE) assay was designed to genotype PCP4-Intron 1, PCP4-3’UTR, SEMA3D, CD109-intron 2 and CD109-intron 8 markers and a McNemar’s test was performed on the matched pairs. An association with these five markers was not detected with the OJD serostatus in Turkish sheep (power of detection, 0.95; odds ratio >3; McNemar’s p</abstract><pub>Taylor & Francis</pub><doi>10.6084/m9.figshare.14068549</doi><oa>free_for_read</oa></addata></record> |
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| identifier | DOI: 10.6084/m9.figshare.14068549 |
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| subjects | Biological Sciences not elsewhere classified Cancer Environmental Sciences not elsewhere classified FOS: Biological sciences FOS: Earth and related environmental sciences FOS: Mathematics FOS: Sociology Genetics Mathematical Sciences not elsewhere classified Medicine Science Policy Sociology Virology |
| title | Evaluation of CD109, PCP4 and SEMA3D genes for their association with Ovine Johne’s disease in Turkish sheep |
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