Additional file 5 of Three-dimensional vascular microenvironment landscape in human glioblastoma

Additional file 5: Supplementary Figure S4. Aberrant COL-IV deposition in GBM. a Concentric multilayered deposition (1), concentric layers and granulated dispersed COL-IV deposition (2), aberrant deposition in large vascular structures (3). b Multilayered and perforated glomeruloid vessel within a GFAP+ tumor nest region. c Mosaic of hypervascularized node in GBM, GFAP+ (red) neoplastic areas with high deposition of COL-IV (green); CD31+ endothelium (magenta) showing hypertrophic limits of a vascular barrier.