Enrichment of CpG island shore region hypermethylation in epigenetic breast field cancerization
While changes in DNA methylation are known to occur early in breast carcinogenesis and the landscape of breast tumour DNA methylation is profoundly altered compared with normal tissue, there have been limited efforts to identify DNA methylation field cancerization effects in histologically normal br...
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| creator | Muse, Meghan E. Titus, Alexander J. Salas, Lucas A. Wilkins, Owen M. Mullen, Chelsey Gregory, Kelly J. Schneider, Sallie S. Crisi, Giovanna M. Jawale, Rahul M. Otis, Christopher N. Christensen, Brock C. Arcaro, Kathleen F. |
| description | While changes in DNA methylation are known to occur early in breast carcinogenesis and the landscape of breast tumour DNA methylation is profoundly altered compared with normal tissue, there have been limited efforts to identify DNA methylation field cancerization effects in histologically normal breast tissue adjacent to tumour. Matched tumour, histologically normal tissue of the ipsilateral breast (ipsilateral-normal), and histologically normal tissue of the contralateral breast (contralateral-normal) were obtained from nine women undergoing bilateral mastectomy. Laser capture microdissection was used to select epithelial cells from normal tissue, and neoplastic cells from tumour for genome-scale measures of DNA methylation with the Illumina HumanMethylationEPIC array. We identified substantially more CpG loci that were differentially methylated between contralateral-normal and tumour (63,271 CpG loci q q p DCIS: ductal carcinoma in situ; GO: gene ontology; OR: odds ratio; CI: confidence interval; TFBS: transcription factor binding site; LOLA: Locus Overlap Analysis |
| doi_str_mv | 10.6084/m9.figshare.12091902 |
| format | Dataset |
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We identified substantially more CpG loci that were differentially methylated between contralateral-normal and tumour (63,271 CpG loci q q p DCIS: ductal carcinoma in situ; GO: gene ontology; OR: odds ratio; CI: confidence interval; TFBS: transcription factor binding site; LOLA: Locus Overlap Analysis</description><identifier>DOI: 10.6084/m9.figshare.12091902</identifier><language>eng</language><publisher>Taylor & Francis</publisher><subject>Biochemistry ; Biological Sciences not elsewhere classified ; Biophysics ; Cancer ; Cell Biology ; Developmental Biology ; FOS: Biological sciences ; FOS: Physical sciences ; Genetics ; Medicine ; Molecular Biology ; Pharmacology ; Physical Sciences not elsewhere classified ; Plant Biology</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>780,1894</link.rule.ids><linktorsrc>$$Uhttps://commons.datacite.org/doi.org/10.6084/m9.figshare.12091902$$EView_record_in_DataCite.org$$FView_record_in_$$GDataCite.org$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Muse, Meghan E.</creatorcontrib><creatorcontrib>Titus, Alexander J.</creatorcontrib><creatorcontrib>Salas, Lucas A.</creatorcontrib><creatorcontrib>Wilkins, Owen M.</creatorcontrib><creatorcontrib>Mullen, Chelsey</creatorcontrib><creatorcontrib>Gregory, Kelly J.</creatorcontrib><creatorcontrib>Schneider, Sallie S.</creatorcontrib><creatorcontrib>Crisi, Giovanna M.</creatorcontrib><creatorcontrib>Jawale, Rahul M.</creatorcontrib><creatorcontrib>Otis, Christopher N.</creatorcontrib><creatorcontrib>Christensen, Brock C.</creatorcontrib><creatorcontrib>Arcaro, Kathleen F.</creatorcontrib><title>Enrichment of CpG island shore region hypermethylation in epigenetic breast field cancerization</title><description>While changes in DNA methylation are known to occur early in breast carcinogenesis and the landscape of breast tumour DNA methylation is profoundly altered compared with normal tissue, there have been limited efforts to identify DNA methylation field cancerization effects in histologically normal breast tissue adjacent to tumour. 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| identifier | DOI: 10.6084/m9.figshare.12091902 |
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| subjects | Biochemistry Biological Sciences not elsewhere classified Biophysics Cancer Cell Biology Developmental Biology FOS: Biological sciences FOS: Physical sciences Genetics Medicine Molecular Biology Pharmacology Physical Sciences not elsewhere classified Plant Biology |
| title | Enrichment of CpG island shore region hypermethylation in epigenetic breast field cancerization |
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