Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment
Additional Supplement Data of the manuscript Perez-Garcia J, Espuela-Ortiz A, Hernández-Pérez JM, et al. Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment (in press). J Allergy Clin Immunol. 2023;S0091-6749(23)00748-0. doi:10.1...
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| creator | Perez-Garcia, Javier Espuela-Ortiz, Antonio Hernández-Pérez, José María González-Pérez, Ruperto Poza-Guedes, Paloma Martin-Gonzalez, Elena Eng, Celeste Sardón-Prado, Olaia Mederos-Luis, Elena Corcuera-Elosegui, Paula Sánchez-Machín, Inmaculada Korta-Murua, Javier Villar, Jesús Burchard, Esteban G. Lorenzo-Diaz, Fabian Pino-Yanes, Maria |
| description | Additional Supplement Data of the manuscript Perez-Garcia J, Espuela-Ortiz A, Hernández-Pérez JM, et al. Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment (in press). J Allergy Clin Immunol. 2023;S0091-6749(23)00748-0. doi:10.1016/j.jaci.2023.05.021. This Supplement Data contains the following items: Additional Table 1 List of independent mbQTLs associated with p |
| doi_str_mv | 10.5281/zenodo.7472531 |
| format | Dataset |
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Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment (in press). J Allergy Clin Immunol. 2023;S0091-6749(23)00748-0. doi:10.1016/j.jaci.2023.05.021. This Supplement Data contains the following items: Additional Table 1 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from saliva samples in Europeans (discovery). Additional Table 2 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from pharyngeal samples in Europeans (discovery). Additional Table 3 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from nasal samples in Europeans (discovery). Additional Table 4 Summary results of enrichment analyses using the Enrichr platform. Additional Table 5 Summary results of stratified enrichment analyses by biological sample type. Additional Table 6 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from saliva samples in African Americans (replication phase). Additional Table 7 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from saliva samples in Latinos (replication phase). Additional Table 8 Summary results of replication enrichment analyses in saliva samples. Additional Table 9 Summary statistics of the mbQTL analysis of Streptococcus in nasal samples. Additional Table 10 Summary statistics of the mbQTL analysis of Campylobacter in pharyngeal samples. Additional Table 11 Summary statistics of the mbQTL analysis of Tannerella in pharyngeal samples. Additional Table 12 Summary table of the different genetic models tested for each mbQTL pair.</description><identifier>DOI: 10.5281/zenodo.7472531</identifier><language>eng</language><publisher>Zenodo</publisher><subject>asthma ; exacerbations ; mbGWAS ; mbQTL ; microbiome</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-0332-437X ; 0000-0001-7813-4381 ; 0000-0003-0572-9549 ; 0000-0002-3398-198X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>778,1890</link.rule.ids><linktorsrc>$$Uhttps://commons.datacite.org/doi.org/10.5281/zenodo.7472531$$EView_record_in_DataCite.org$$FView_record_in_$$GDataCite.org$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Perez-Garcia, Javier</creatorcontrib><creatorcontrib>Espuela-Ortiz, Antonio</creatorcontrib><creatorcontrib>Hernández-Pérez, José María</creatorcontrib><creatorcontrib>González-Pérez, Ruperto</creatorcontrib><creatorcontrib>Poza-Guedes, Paloma</creatorcontrib><creatorcontrib>Martin-Gonzalez, Elena</creatorcontrib><creatorcontrib>Eng, Celeste</creatorcontrib><creatorcontrib>Sardón-Prado, Olaia</creatorcontrib><creatorcontrib>Mederos-Luis, Elena</creatorcontrib><creatorcontrib>Corcuera-Elosegui, Paula</creatorcontrib><creatorcontrib>Sánchez-Machín, Inmaculada</creatorcontrib><creatorcontrib>Korta-Murua, Javier</creatorcontrib><creatorcontrib>Villar, Jesús</creatorcontrib><creatorcontrib>Burchard, Esteban G.</creatorcontrib><creatorcontrib>Lorenzo-Diaz, Fabian</creatorcontrib><creatorcontrib>Pino-Yanes, Maria</creatorcontrib><title>Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment</title><description>Additional Supplement Data of the manuscript Perez-Garcia J, Espuela-Ortiz A, Hernández-Pérez JM, et al. Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment (in press). J Allergy Clin Immunol. 2023;S0091-6749(23)00748-0. doi:10.1016/j.jaci.2023.05.021. This Supplement Data contains the following items: Additional Table 1 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from saliva samples in Europeans (discovery). Additional Table 2 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from pharyngeal samples in Europeans (discovery). Additional Table 3 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from nasal samples in Europeans (discovery). Additional Table 4 Summary results of enrichment analyses using the Enrichr platform. Additional Table 5 Summary results of stratified enrichment analyses by biological sample type. Additional Table 6 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from saliva samples in African Americans (replication phase). Additional Table 7 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from saliva samples in Latinos (replication phase). Additional Table 8 Summary results of replication enrichment analyses in saliva samples. Additional Table 9 Summary statistics of the mbQTL analysis of Streptococcus in nasal samples. Additional Table 10 Summary statistics of the mbQTL analysis of Campylobacter in pharyngeal samples. Additional Table 11 Summary statistics of the mbQTL analysis of Tannerella in pharyngeal samples. Additional Table 12 Summary table of the different genetic models tested for each mbQTL pair.</description><subject>asthma</subject><subject>exacerbations</subject><subject>mbGWAS</subject><subject>mbQTL</subject><subject>microbiome</subject><fulltext>true</fulltext><rsrctype>dataset</rsrctype><creationdate>2023</creationdate><recordtype>dataset</recordtype><sourceid>PQ8</sourceid><recordid>eNotkLFuwjAURbN0qGjXzv6BpLwk2M6IIgpIVF2yR8_2i7CU2JFtUMvXNwimO9yjq6uTZR-wLjalhM8bOW98IWpRbip4zW6Hy4SO7clRsjqyoxvGCzlNkX1bHbyyfiLW-mn20Sbr3UJc_Xglw6xj25jOE7LdL2oKCu99ZIbibBMt4BnHhWt9WKZ9TBS8NawLhGkil96ylwHHSO_PXGXd165rD_npZ39st6fciAZyiZKXQguuBNC6wrJWgFyWJcBA0CjOB25ANlLrmqghrJXmAupK8EFJaKpVVjxmDSbUy7F-DnbC8NfDur876R9O-qeT6h-Rt17L</recordid><startdate>20230608</startdate><enddate>20230608</enddate><creator>Perez-Garcia, Javier</creator><creator>Espuela-Ortiz, Antonio</creator><creator>Hernández-Pérez, José María</creator><creator>González-Pérez, Ruperto</creator><creator>Poza-Guedes, Paloma</creator><creator>Martin-Gonzalez, Elena</creator><creator>Eng, Celeste</creator><creator>Sardón-Prado, Olaia</creator><creator>Mederos-Luis, Elena</creator><creator>Corcuera-Elosegui, Paula</creator><creator>Sánchez-Machín, Inmaculada</creator><creator>Korta-Murua, Javier</creator><creator>Villar, Jesús</creator><creator>Burchard, Esteban G.</creator><creator>Lorenzo-Diaz, Fabian</creator><creator>Pino-Yanes, Maria</creator><general>Zenodo</general><scope>DYCCY</scope><scope>PQ8</scope><orcidid>https://orcid.org/0000-0003-0332-437X</orcidid><orcidid>https://orcid.org/0000-0001-7813-4381</orcidid><orcidid>https://orcid.org/0000-0003-0572-9549</orcidid><orcidid>https://orcid.org/0000-0002-3398-198X</orcidid></search><sort><creationdate>20230608</creationdate><title>Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment</title><author>Perez-Garcia, Javier ; Espuela-Ortiz, Antonio ; Hernández-Pérez, José María ; González-Pérez, Ruperto ; Poza-Guedes, Paloma ; Martin-Gonzalez, Elena ; Eng, Celeste ; Sardón-Prado, Olaia ; Mederos-Luis, Elena ; Corcuera-Elosegui, Paula ; Sánchez-Machín, Inmaculada ; Korta-Murua, Javier ; Villar, Jesús ; Burchard, Esteban G. ; Lorenzo-Diaz, Fabian ; Pino-Yanes, Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-d791-8a8627c76b71e03a24b1a682211fe19b66f6d1898cc4ee9ea4bc6714376fb8193</frbrgroupid><rsrctype>datasets</rsrctype><prefilter>datasets</prefilter><language>eng</language><creationdate>2023</creationdate><topic>asthma</topic><topic>exacerbations</topic><topic>mbGWAS</topic><topic>mbQTL</topic><topic>microbiome</topic><toplevel>online_resources</toplevel><creatorcontrib>Perez-Garcia, Javier</creatorcontrib><creatorcontrib>Espuela-Ortiz, Antonio</creatorcontrib><creatorcontrib>Hernández-Pérez, José María</creatorcontrib><creatorcontrib>González-Pérez, Ruperto</creatorcontrib><creatorcontrib>Poza-Guedes, Paloma</creatorcontrib><creatorcontrib>Martin-Gonzalez, Elena</creatorcontrib><creatorcontrib>Eng, Celeste</creatorcontrib><creatorcontrib>Sardón-Prado, Olaia</creatorcontrib><creatorcontrib>Mederos-Luis, Elena</creatorcontrib><creatorcontrib>Corcuera-Elosegui, Paula</creatorcontrib><creatorcontrib>Sánchez-Machín, Inmaculada</creatorcontrib><creatorcontrib>Korta-Murua, Javier</creatorcontrib><creatorcontrib>Villar, Jesús</creatorcontrib><creatorcontrib>Burchard, Esteban G.</creatorcontrib><creatorcontrib>Lorenzo-Diaz, Fabian</creatorcontrib><creatorcontrib>Pino-Yanes, Maria</creatorcontrib><collection>DataCite (Open Access)</collection><collection>DataCite</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Perez-Garcia, Javier</au><au>Espuela-Ortiz, Antonio</au><au>Hernández-Pérez, José María</au><au>González-Pérez, Ruperto</au><au>Poza-Guedes, Paloma</au><au>Martin-Gonzalez, Elena</au><au>Eng, Celeste</au><au>Sardón-Prado, Olaia</au><au>Mederos-Luis, Elena</au><au>Corcuera-Elosegui, Paula</au><au>Sánchez-Machín, Inmaculada</au><au>Korta-Murua, Javier</au><au>Villar, Jesús</au><au>Burchard, Esteban G.</au><au>Lorenzo-Diaz, Fabian</au><au>Pino-Yanes, Maria</au><format>book</format><genre>unknown</genre><ristype>DATA</ristype><title>Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment</title><date>2023-06-08</date><risdate>2023</risdate><abstract>Additional Supplement Data of the manuscript Perez-Garcia J, Espuela-Ortiz A, Hernández-Pérez JM, et al. Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment (in press). J Allergy Clin Immunol. 2023;S0091-6749(23)00748-0. doi:10.1016/j.jaci.2023.05.021. This Supplement Data contains the following items: Additional Table 1 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from saliva samples in Europeans (discovery). Additional Table 2 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from pharyngeal samples in Europeans (discovery). Additional Table 3 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from nasal samples in Europeans (discovery). Additional Table 4 Summary results of enrichment analyses using the Enrichr platform. Additional Table 5 Summary results of stratified enrichment analyses by biological sample type. Additional Table 6 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from saliva samples in African Americans (replication phase). Additional Table 7 List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from saliva samples in Latinos (replication phase). Additional Table 8 Summary results of replication enrichment analyses in saliva samples. Additional Table 9 Summary statistics of the mbQTL analysis of Streptococcus in nasal samples. Additional Table 10 Summary statistics of the mbQTL analysis of Campylobacter in pharyngeal samples. Additional Table 11 Summary statistics of the mbQTL analysis of Tannerella in pharyngeal samples. Additional Table 12 Summary table of the different genetic models tested for each mbQTL pair.</abstract><pub>Zenodo</pub><doi>10.5281/zenodo.7472531</doi><orcidid>https://orcid.org/0000-0003-0332-437X</orcidid><orcidid>https://orcid.org/0000-0001-7813-4381</orcidid><orcidid>https://orcid.org/0000-0003-0572-9549</orcidid><orcidid>https://orcid.org/0000-0002-3398-198X</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | DataCite |
| subjects | asthma exacerbations mbGWAS mbQTL microbiome |
| title | Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment |
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