Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans

To survive elevated temperatures, ectotherms adjust the fluidity of membranes by fine-tuning lipid desaturation levels in a process previously described to be cell-autonomous. We have discovered that, in Caenorhabditis elegans, neuronal Heat shock Factor 1 (HSF-1), the conserved master regulator of...

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Hauptverfasser:	Chauve, Laetitia, Hodge, Francesca, Murdoch, Sharlene, Masoudzadeh, Fatemah, Mann, Harry-Jack, Lopez-Clavijo, Andrea, Okkenhaug, Hanneke, West, Greg, Sousa, Bebiana C., Segonds-Pichon, Anne, Li, Cheryl, Wingett, Steven, Kienberger, Hermine, Kleigrewe, Karin, De Bono, Mario, Wakelam, Michael, Casanueva, Olivia
Format:	Dataset
Sprache:	eng
Schlagworte:	Ageing Aging C. elegans fat metabolism heat shock factor 1 Neuron
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