Link to dataset related to article "Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth "
This record contains raw data related to article “ Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth" The microbiota has been shown to promote intestinal tumourigenesis, but a possible anti-tumourigenic effect has also bee...
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| creator | Zagato, Elena Pozzi, Chiara Bertocchi, Alice Schioppa, Tiziana Saccheri, Fabiana Guglietta, Silvia Fosso, Bruno Melocchi, Laura Nizzoli, Giulia Troisi, Jacopo Marzano, Marinella Oresta, Bianca Spadoni, Ilaria Atarashi, Koji Carloni, Sara Arioli, Stefania Fornasa, Giulia Asnicar, Francesco Segata, Nicola Guglielmetti, Simone Honda, Kenya Pesole, Graziano Vermi, William Penna, Giuseppe Rescigno, Maria |
| description | This record contains raw data related to article “ Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth" The microbiota has been shown to promote intestinal tumourigenesis, but a possible anti-tumourigenic effect has also been postulated. Here, we demonstrate that changes in the microbiota and mucus composition are concomitant with tumourigenesis. We identified two anti-tumourigenic strains of the microbiota-Faecalibaculum rodentium and its human homologue, Holdemanella biformis-that are strongly under-represented during tumourigenesis. Reconstitution of ApcMin/+ or azoxymethane- and dextran sulfate sodium-treated mice with an isolate of F. rodentium (F. PB1) or its metabolic products reduced tumour growth. Both F. PB1 and H. biformis produced short-chain fatty acids that contributed to control protein acetylation and tumour cell proliferation by inhibiting calcineurin and NFATc3 activation in mouse and human settings. We have thus identified endogenous anti-tumourigenic bacterial strains with strong diagnostic, therapeutic and translational potential. |
| doi_str_mv | 10.5281/zenodo.4359912 |
| format | Dataset |
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Here, we demonstrate that changes in the microbiota and mucus composition are concomitant with tumourigenesis. We identified two anti-tumourigenic strains of the microbiota-Faecalibaculum rodentium and its human homologue, Holdemanella biformis-that are strongly under-represented during tumourigenesis. Reconstitution of ApcMin/+ or azoxymethane- and dextran sulfate sodium-treated mice with an isolate of F. rodentium (F. PB1) or its metabolic products reduced tumour growth. Both F. PB1 and H. biformis produced short-chain fatty acids that contributed to control protein acetylation and tumour cell proliferation by inhibiting calcineurin and NFATc3 activation in mouse and human settings. 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Here, we demonstrate that changes in the microbiota and mucus composition are concomitant with tumourigenesis. We identified two anti-tumourigenic strains of the microbiota-Faecalibaculum rodentium and its human homologue, Holdemanella biformis-that are strongly under-represented during tumourigenesis. Reconstitution of ApcMin/+ or azoxymethane- and dextran sulfate sodium-treated mice with an isolate of F. rodentium (F. PB1) or its metabolic products reduced tumour growth. Both F. PB1 and H. biformis produced short-chain fatty acids that contributed to control protein acetylation and tumour cell proliferation by inhibiting calcineurin and NFATc3 activation in mouse and human settings. 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| identifier | DOI: 10.5281/zenodo.4359912 |
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| recordid | cdi_datacite_primary_10_5281_zenodo_4359912 |
| source | DataCite |
| title | Link to dataset related to article "Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth " |
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