COMPARATIVE EVALUATION OF PERCENTAGE LABEL CLAIM OF DIFFERENT BRANDS OF MARKETED AMLODIPINE

Presence of various brands of similar drug product at different rates creates a question of quality and therapeutic efficacy in the mind of consumer. The marketing practice to promote the brands also invites the confusion among the patients and market middleman. The comparative evaluation of quality parameters gives an idea of difference in therapeutic effectiveness of brands. This study was conducted to understand and analyse the variation in quality parameters of different brands of Amlodipine tablets available in market. In the present work an inexpensive, easy, mercurial, particular,sensible, reproducible, and spectroscopic method has been used for the estimation of amlodipine in pure drug and marketed tablet formulation. Analysis was carried out at 238nm for pure drug amlodipine as well as for amlodipine marketed tablet formulation. The main purpose of the investigation was to measure that how much percentage of drug present in marketed tablet formulation for the estimation of amlodipine besylate tablet and amlodipine pure drug using distilled water as a solvent. Key Words: UV Spectroscopy, Amlodipine, Methodology,