Backpain exercise therapy remodels human epigenetic profiles in buccal and human peripheral blood mononuclear cells: An exploratory study in young male participants

### Files description ### Notes. 1) "BT" refers to before therapy and "AT" to after therapy. 2) 0 refers to FALSE and 1 to TRUE for binary variables. The provided files have tab-separated columns except the .RDS which is and R output of the mixOmics DIABLO integration analysis. # Questionnaire > participants_categories.tsv: per participant (rows), output of the clustering with the participant ("ID") category ("category") per class ("class") > questionnaire_agility_metrics.tsv: questionnaire and agility metrics per participant (rows) for the participants ("ID") with at least one paired AT+BT data in one type of biological sample (indicated in the columns "swab", "PBMC", and "plasma") # PTMs Samples´ names are encoded as PBMC_AT_8_batch1, i.e. cells origin_time upon therapy_ID_batch (we removed _batch column suffix for the processed files). NA indicates an undetected intensity. > raw_PBMC_light_labelled_intensities.tsv: raw intensity of light/endogenous peptides (row) by precursor per sample (column) from PBMC > raw_swab_light_labelled_intensities.tsv: idem from buccal cells > raw_PBMC_heavy_labelled_intensities.tsv: raw intensity of light/endogenous peptides (row) by precursor per sample (column) from PBMC > raw_swab_heavy_labelled_intensities.tsv: idem from buccal cells > raw_PBMC_heavynormalized_intensities.tsv: raw intensity of light peptides normalized by heavy peptides intensity (row) by precursor per sample (column) > raw_swab_heavynormalized_labelled_intensities.tsv: idem from buccal cells > processed_cleaned_PBMC_log2intensities.tsv: processed (heavy normalized, imputed, batch-corrected) intensity of peptides aggregated by modification (PTM, row) by precursor per sample (column) after log2-transformation. The relative abundances are computed from this file. Rows without me/ac suffix represents the amount of unmodified peptide for the considered site. > processed_cleaned_swab_log2intensities.tsv: idem from buccal cells > rel_abundance_PTM_PBMC.tsv: relative abundance computed per precursor, e.g. for a given sample, the H3_K4+H3_K4me1+H3_K4me2+H3_K4me3 relative abundance values must sum to 100, with the relative abundance of H3_K4 representing the absence of modified K4. > rel_abundance_PTM_swab.tsv: idem from buccal cells > tests_from_rel_abundance_PTM_swab_PBMC.tsv: per type of samples ("Sample.origin", i.e.swab of PBMC) and per PTM (rows, "PTM"), report the output of classic (p-values, adjusted with Benjamini-Hochberg (BH), or Benjamini-Yekutieli p