Synapsin E-domain is essential for a-synuclein function
The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is lacking. Here we identify the synapsin E-domain as an essential functional binding-partner of a-synuclein (a-syn). Synapsin E-domain allows...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Dataset |
| Sprache: | eng |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | Parra Rivas, Leonardo |
| description | The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is lacking. Here we identify the synapsin E-domain as an essential functional binding-partner of a-synuclein (a-syn). Synapsin E-domain allows a-syn functionality, binds to a-syn, and is necessary and sufficient for enabling effects of a-syn at the synapse. Together with previous studies implicating the E-domain in clustering SVs, our experiments advocate a cooperative role for these two proteins in maintaining physiologic SV clusters. |
| doi_str_mv | 10.5281/zenodo.10254061 |
| format | Dataset |
| fullrecord | <record><control><sourceid>datacite_PQ8</sourceid><recordid>TN_cdi_datacite_primary_10_5281_zenodo_10254061</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_5281_zenodo_10254061</sourcerecordid><originalsourceid>FETCH-datacite_primary_10_5281_zenodo_102540613</originalsourceid><addsrcrecordid>eNpjYBA3NNAzNbIw1K9KzctPydczNDAyNTEwM-RkMA-uzEssKM7MU3DVTcnPTQQyMosVUouLU_NKMhNzFNLyixQSdYsr80qTc1KBkmmlecklmfl5PAysaYk5xam8UJqbQd_NNcTZQzclsSQxObMkNb6gKDM3sagy3tAgHmR1PMTqeJjVxqTrAAAH1z4R</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>dataset</recordtype></control><display><type>dataset</type><title>Synapsin E-domain is essential for a-synuclein function</title><source>DataCite</source><creator>Parra Rivas, Leonardo</creator><creatorcontrib>Parra Rivas, Leonardo</creatorcontrib><description>The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is lacking. Here we identify the synapsin E-domain as an essential functional binding-partner of a-synuclein (a-syn). Synapsin E-domain allows a-syn functionality, binds to a-syn, and is necessary and sufficient for enabling effects of a-syn at the synapse. Together with previous studies implicating the E-domain in clustering SVs, our experiments advocate a cooperative role for these two proteins in maintaining physiologic SV clusters. </description><identifier>DOI: 10.5281/zenodo.10254061</identifier><language>eng</language><publisher>Zenodo</publisher><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-6707-1255</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>776,1888</link.rule.ids><linktorsrc>$$Uhttps://commons.datacite.org/doi.org/10.5281/zenodo.10254061$$EView_record_in_DataCite.org$$FView_record_in_$$GDataCite.org$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Parra Rivas, Leonardo</creatorcontrib><title>Synapsin E-domain is essential for a-synuclein function</title><description>The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is lacking. Here we identify the synapsin E-domain as an essential functional binding-partner of a-synuclein (a-syn). Synapsin E-domain allows a-syn functionality, binds to a-syn, and is necessary and sufficient for enabling effects of a-syn at the synapse. Together with previous studies implicating the E-domain in clustering SVs, our experiments advocate a cooperative role for these two proteins in maintaining physiologic SV clusters. </description><fulltext>true</fulltext><rsrctype>dataset</rsrctype><creationdate>2023</creationdate><recordtype>dataset</recordtype><sourceid>PQ8</sourceid><recordid>eNpjYBA3NNAzNbIw1K9KzctPydczNDAyNTEwM-RkMA-uzEssKM7MU3DVTcnPTQQyMosVUouLU_NKMhNzFNLyixQSdYsr80qTc1KBkmmlecklmfl5PAysaYk5xam8UJqbQd_NNcTZQzclsSQxObMkNb6gKDM3sagy3tAgHmR1PMTqeJjVxqTrAAAH1z4R</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Parra Rivas, Leonardo</creator><general>Zenodo</general><scope>DYCCY</scope><scope>PQ8</scope><orcidid>https://orcid.org/0000-0002-6707-1255</orcidid></search><sort><creationdate>202308</creationdate><title>Synapsin E-domain is essential for a-synuclein function</title><author>Parra Rivas, Leonardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-datacite_primary_10_5281_zenodo_102540613</frbrgroupid><rsrctype>datasets</rsrctype><prefilter>datasets</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Parra Rivas, Leonardo</creatorcontrib><collection>DataCite (Open Access)</collection><collection>DataCite</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Parra Rivas, Leonardo</au><format>book</format><genre>unknown</genre><ristype>DATA</ristype><title>Synapsin E-domain is essential for a-synuclein function</title><date>2023-08</date><risdate>2023</risdate><abstract>The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is lacking. Here we identify the synapsin E-domain as an essential functional binding-partner of a-synuclein (a-syn). Synapsin E-domain allows a-syn functionality, binds to a-syn, and is necessary and sufficient for enabling effects of a-syn at the synapse. Together with previous studies implicating the E-domain in clustering SVs, our experiments advocate a cooperative role for these two proteins in maintaining physiologic SV clusters. </abstract><pub>Zenodo</pub><doi>10.5281/zenodo.10254061</doi><orcidid>https://orcid.org/0000-0002-6707-1255</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | DOI: 10.5281/zenodo.10254061 |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_datacite_primary_10_5281_zenodo_10254061 |
| source | DataCite |
| title | Synapsin E-domain is essential for a-synuclein function |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T01%3A52%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-datacite_PQ8&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=unknown&rft.au=Parra%20Rivas,%20Leonardo&rft.date=2023-08&rft_id=info:doi/10.5281/zenodo.10254061&rft_dat=%3Cdatacite_PQ8%3E10_5281_zenodo_10254061%3C/datacite_PQ8%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |