Parallel CRISPR-Cas9 screens clarify impacts of p53 on screen performance

CRISPR-Cas9 genome engineering has revolutionised high-throughput functional genomic screens. However, recent work has raised concerns regarding the performance of CRISPR-Cas9 screens using TP53 wild-type human cells due to a p53-mediated DNA damage response (DDR) limiting the efficiency of generati...

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Bibliographische Detailangaben

Hauptverfasser:	Bowden, A Ramsay, Morales Juarez, David A., Sczaniecka-Clift, Matylda, Agudo, Maria M., Lukashchuk, Natalia, Thomas, John C., Jackson, Stephen P.
Format:	Dataset
Sprache:	eng
Schlagworte:	CRISPR CRISPR screening DNA damage dna damage response TP53
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