Bioanalysis of the Bicycle R ? toxin conjugateBT5528 and released monomethyl auristatinE via liquid chromatography–tandem massspectrometry: supplementary materials

Background: The Bicycle R ? toxin conjugate BT5528 is a novel peptide therapeutic conjugated to thecytotoxic agent monomethyl auristatin E (MMAE). A bioanalytical assay was developed to quantifyBT5528 and unconjugated MMAE in human plasma. Methodology: BT5528 quantitation used a proteinprecipitation...

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Hauptverfasser:	A Tweed, Joseph, Adams-Dam, Fern, Allanson, Jane, Holmes, Kevin, Senior, Ryan, Xu, Hongmei, Li, Mengyao, Bennett, Gavin, Jeffrey, Phil
Format:	Dataset
Sprache:	eng
Online-Zugang:	Volltext bestellen
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