Ultrasensitive digital immunoassays for SOD1 conformation in amyotrophic lateral sclerosis: supplementary figures
Aim: The aim of this study was to detect misfolded Cu/Zn SOD1 as a potential biomarker for amyotrophiclateral sclerosis (ALS). Materials & methods: Two ultrasensitive immunodetection assays were developedfor the quantification of total and misfolded SOD1. Results: The detection of total and misf...
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| creator | Morichon, Lisa Hirtz, Christophe Tiers, Laurent Mezghrani, Alexandre Raoul, Cedric Esselin, Florence De La Cruz, Elisa Julien, Jean-Pierre Camu, William Lehmann, Sylvain |
| description | Aim: The aim of this study was to detect misfolded Cu/Zn SOD1 as a potential biomarker for amyotrophiclateral sclerosis (ALS). Materials & methods: Two ultrasensitive immunodetection assays were developedfor the quantification of total and misfolded SOD1. Results: The detection of total and misfoldedSOD1 was possible in human serum and cerebrospinal fluid. Total SOD1 was increased in cerebrospinalfluid from ALS patients. Misfolded SOD1 had low and variable expression in both control and ALS patientsamples. Conclusion: These assays hold promise for improving our understanding of ALS and its detection,and could lead to more effective treatment options in the future. Further studies in larger cohorts are nowrequired. |
| doi_str_mv | 10.25402/bio.24064902 |
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Materials & methods: Two ultrasensitive immunodetection assays were developedfor the quantification of total and misfolded SOD1. Results: The detection of total and misfoldedSOD1 was possible in human serum and cerebrospinal fluid. Total SOD1 was increased in cerebrospinalfluid from ALS patients. Misfolded SOD1 had low and variable expression in both control and ALS patientsamples. Conclusion: These assays hold promise for improving our understanding of ALS and its detection,and could lead to more effective treatment options in the future. 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Materials & methods: Two ultrasensitive immunodetection assays were developedfor the quantification of total and misfolded SOD1. Results: The detection of total and misfoldedSOD1 was possible in human serum and cerebrospinal fluid. Total SOD1 was increased in cerebrospinalfluid from ALS patients. Misfolded SOD1 had low and variable expression in both control and ALS patientsamples. Conclusion: These assays hold promise for improving our understanding of ALS and its detection,and could lead to more effective treatment options in the future. 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| title | Ultrasensitive digital immunoassays for SOD1 conformation in amyotrophic lateral sclerosis: supplementary figures |
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