A dataset for oxytocin loaded nanoparticles and their effects on pentylenetetrazole-kindling model of male rats

A dataset for oxytocin loaded nanoparticles and their effects on pentylenetetrazole-kindling model of male rats

Temporal lob epilepsy (TLE) related to hippocampus is characterized with seizures. Memory-related cognitive abnormalities are important problems with this disorder. Pentilentetrazol (PTZ)-kindling is one of the models which is applied on rodents in order to investigate TLE. Findings for the histopat...

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description Temporal lob epilepsy (TLE) related to hippocampus is characterized with seizures. Memory-related cognitive abnormalities are important problems with this disorder. Pentilentetrazol (PTZ)-kindling is one of the models which is applied on rodents in order to investigate TLE. Findings for the histopathology of hippocampus are like decrease of neurogenesis, and short-time memory alterations are seen in the PTZ-kindling model which are also related to human TLE. Although exogenously application of oxytocin (OT) hormone researches are increasing for the effects of brain and related pathophysiologies, epilepsy-related studies are highly limited. According to previous data about OT application for non-invasive and efficiently passing through the brain, it is seen that intranasal (IN) pathway and OT loaded nanoparticles (NP-OTs) are prominent methods for that issue. This study aims IN administrated NP-OTs and their effects on pentylenetetrazole-kindling model of male rats This dataset includes some data of the author's master thesis found in Council of Education Thesis Center (https://tez.yok.gov.tr/UlusalTezMerkezi/giris.jsp) with the 657706 thesis number.
doi_str_mv 10.17632/vrpw86vx8f.4
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title A dataset for oxytocin loaded nanoparticles and their effects on pentylenetetrazole-kindling model of male rats
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