TMUB1 promotes p97-mediated segregation of hydrophobic transmembrane domains from the endoplasmic reticulum membrane
Membrane protein clients of endoplasmic reticulum (ER)-associated degradation must be retrotranslocated from the ER membrane by the AAA-ATPase p97 for proteasomal degradation. Before direct engagement with p97, client transmembrane domains (TMDs) that have partially or fully crossed the membrane mus...
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