Single cell RNAseq-based proteogenomics identifies glioblastoma-specific transposable elements encoding HLA-presented peptides
We developed a transposable element (TE)-centered proteogenomic pipeline that combines single cell transcriptomics on tumors from glioblastoma (GBM) patients, bulk RNAseq samples from tumor and healthy tissue cohorts, and immunopeptidomics. We thus identified 370 HLA-I-bound peptides encoded by TEs...
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