Enzyme-Powered Porous Micromotors Built from a Hierarchical Micro- And Mesoporous UiO-Type Metal-Organic Framework

Enzyme-Powered Porous Micromotors Built from a Hierarchical Micro- And Mesoporous UiO-Type Metal-Organic Framework

Here, we report the design, synthesis, and functional testing of enzyme-powered porous micromotors built from a metal-organic framework (MOF). We began by subjecting a presynthesized microporous UiO-type MOF to ozonolysis, to confer it with mesopores sufficiently large to adsorb and host the enzyme...

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Bibliographische Detailangaben
Hauptverfasser: Yang, Yunhui, Arqué, Xavier, Patiño, Tania, Guillerm, Vincent, Blersch, Pascal Raphael, Pérez-Carvajal, Javier, Imaz, Inhar, Maspoch Comamala, Daniel, Sánchez Ordóñez, Samuel
Format: Artikel
Sprache:eng
Schlagworte:
Biocatalysis
Catalase
Enzymatic generation
Enzyme catalase
Free spaces
Functional testing
Hierarchical pore systems
Metal-Organic Frameworks
Microporous
Oxygen bubbles
Porosity
Self propulsion
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Beschreibung
Zusammenfassung:Here, we report the design, synthesis, and functional testing of enzyme-powered porous micromotors built from a metal-organic framework (MOF). We began by subjecting a presynthesized microporous UiO-type MOF to ozonolysis, to confer it with mesopores sufficiently large to adsorb and host the enzyme catalase (size: 6-10 nm). We then encapsulated catalase inside the mesopores, observing that they are hosted in those mesopores located at the subsurface of the MOF crystals. In the presence of H2O2 fuel, MOF motors (or MOFtors) exhibit jet-like propulsion enabled by enzymatic generation of oxygen bubbles. Moreover, thanks to their hierarchical pore system, the MOFtors retain sufficient free space for adsorption of additional targeted species, which we validated by testing a MOFtor for removal of rhodamine B during self-propulsion.