Stereoselectivity of Proline-Cyclobutane amino acid-containing peptide organocatalysts for asymmetric aldol additions : A rationale
Several α,β,α- or α,γ,α-tripeptides, consisting of a central cyclobutane β- or γ-amino acid being flanked by two d- or l-proline residues, have been synthesized and tested as organocatalysts in asymmetric aldol additions. High yields and enantioselectivities have been achieved with α,γ,α-tripeptides...
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