CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic Beta Cells Independently of Glucose Concentration and Is Regulated by Inflammation in the NOD Mouse Model

Altres ajuts: Generalitat Valenciana (PROMETEO/2011/080), Universitat de Lleida (TR265 no. A001E-12132/2009) Pancreatic islets are exposed to strong pro-apoptotic stimuli: inflammation and hyperglycemia, during the progression of the autoimmune diabetes (T1D). We found that the Cdk11(Cyclin Dependen...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	Sala, Ester, Vived, Celia, Luna, Júlia, Saavedra-Ávila, Noemí Alejandra, Sengupta, Upasana, Castaño, A. Raul, Villar-Pazos, Sabrina, Haba, Laura, Verdaguer, Joan, Ropero, Ana B, Stratmann, Thomas, Pizarro, Javier, Vázquez-Carrera, Manuel, Nadal, Angel, Lahti, Jill M, Mora, Conchi
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Beta cell CDK11 Cyclin D3 Glucose Inflammation Insulin Type 1 diabetes
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!