Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity

Guaianolides are an important class of sesquiterpene lactones with unique biological and pharmaceutical properties. They have been postulated to be derived from germacranolides, but for years no progress has been made in the elucidation of their biosynthesis that requires an unknown cyclization mech...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	Liu, Qing, Beyraghdar Kashkooli, Arman, Manzano, David, Pateraki, Irini, Richard, Lea, Kolkman, Pim, Lucas, Maria Fátima, Guallar, Victor, de Vos, Ric C.H, Franssen, Maurice C.R, van der Krol, Alexander, Bouwmeester, Harro
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosynthetic Pathways Cyclization Cytochrome P-450 Enzyme System Hydroxylation Molecular Docking Simulation Saccharomyces cerevisiae Sesquiterpenes Tanacetum Tobacco
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!