Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice

This study addressed the contribution of acidic sphingomyelinase (ASMase) in TNF-alpha-mediated hepatocellular apoptosis. Cultured hepatocytes depleted of mitochondrial glutathione (mGSH) became sensitive to TNF-alpha, undergoing a time-dependent apoptotic cell death preceded by mitochondrial membra...

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Veröffentlicht in:	The Journal of clinical investigation 2003, Vol.111 (2), p.197-208
Hauptverfasser:	García-Ruiz, Carmen, Colell, Anna, Marí, Montserrat, Morales, Albert, Calvo, María, Enrich, Carlos, Fernández-Checa, José C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosi Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein Cells, Cultured Ceramides - physiology Cèl·lules hepàtiques Gangliosides - physiology Glutathione - metabolism Glycosphingolipids - physiology Hepatocytes Hepatocytes - drug effects Hepatocytes - pathology Liver - drug effects Liver - pathology Medicaments Mice Mice, Inbred C57BL Mice, Knockout Mitochondria, Liver - metabolism NF-kappa B - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 Sphingomyelin Phosphodiesterase - physiology Tumor Necrosis Factor-alpha - pharmacology
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