Genetic heterogeneity and actionable mutations in HER2-positive primary breast cancers and their brain metastases

Brain metastases constitute a challenge in the management of patients with HER2-positive breast cancer treated with anti-HER2 systemic therapies. Here we sought to define the repertoire of mutations private to or enriched for in HER2-positive brain metastases. Massively parallel sequencing targeting...

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Hauptverfasser:	De Mattos-Arruda, Leticia, Ng, Charlotte K. Y, Piscuoglio, Salvatore, Gonzalez-Cao, Maria, Lim, Raymond S, De Filippo, Maria R, Fusco, Nicola, Schultheis, Anne M, Ortiz, Carolina, Viteri, Santiago, Arias, Alexandra, Macedo, Gabriel S, Oliveira, Mafalda, Gómez, Patricia, Teixidó, Cristina, Nuciforo, Paolo, Peg, Vicente, Saura, Cristina, Ramón y Cajal, Santiago, Tresserra Casas, Francesc, Weigelt, Britta, Cortés, Javier, Seoane Suárez, Joan, Reis-Filho, Jorge S
Format:	Artikel
Sprache:	eng
Schlagworte:	Actionable genetic alterations Brain metastasis HER2-positive Metastatic breast cancer Personalized medicine
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