The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo

G protein-coupled receptor 37 (GPR37) is an orphan receptor associated to Parkinson's disease (PD) neuropathology. Here, we identified GPR37 as an inhibitor of adenosine A2A receptor (A2AR) cell surface expression and function in vivo. In addition, we showed that GPR37 and A2AR do oligomerize i...

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Veröffentlicht in:	Scientific reports 2017-08
Hauptverfasser:	Morató Arús, Xavier, Luján, Rafael, López-Cano, Marc, Gandía Sánchez, Jorge, Stagljar, Igor, Watanabe, Masahiko, Cunha, Rodrigo A, Fernández Dueñas, Víctor, Ciruela Alférez, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosina Adenosine Biochemical markers G Proteins Malaltia de Parkinson Marcadors bioquímics Neurotransmitter receptors Parkinson's disease Proteïnes G Receptors de neurotransmissors
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