PBF509, an adenosine A(2A) receptor antagonist with efficacy in rodent models of movement disorders

Adenosine A2A receptor (A2AR) antagonists have emerged as complementary non-dopaminergic drugs to alleviate Parkinson's disease (PD) symptomatology. Here, we characterize a novel non-xhantine non-furan A2AR antagonist, PBF509, as a potential pro-dopaminergic drug for PD management. First, PBF50...

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Veröffentlicht in:	Frontiers in pharmacology 2018-10
Hauptverfasser:	Núñez, Fabiana, Taura, Jaume, Camacho, Juan, López-Cano, Marc, Fernández Dueñas, Víctor, Castro, Naomi, Castro, Julio, Ciruela Alférez, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosina Adenosine Malaltia de Parkinson Neural receptor Parkinson's disease Receptors neurals Tremolor Tremor
Online-Zugang:	Volltext
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