Porous titanium-hydroxyapatite composite coating obtained on titanium by cold gas spray with high bond strength for biomedical applications
[Display omitted] •A titanium-hydroxyapatite coating was produced on titanium by Cold Gas Spray.•Higher adhesion and bond strengths values were obtained compared to other methods.•Cold Gas Spray does not produce any change in hydroxyapatite and titanium phases.•Osteoblasts adhere, proliferate and di...
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| Veröffentlicht in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2019-08, Vol.180, p.245-253 |
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| container_title | Colloids and surfaces, B, Biointerfaces |
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| creator | Guillem-Marti, Jordi Cinca, Núria Punset, Miquel Cano, Irene García Gil, Francisco Javier Guilemany, Jose Maria Dosta, Sergi |
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•A titanium-hydroxyapatite coating was produced on titanium by Cold Gas Spray.•Higher adhesion and bond strengths values were obtained compared to other methods.•Cold Gas Spray does not produce any change in hydroxyapatite and titanium phases.•Osteoblasts adhere, proliferate and differentiate on the Ti-HA coated surfaces.
The lack of bioactivity of titanium (Ti) is one of the main drawbacks for its application in biomedical implants since it can considerable reduce its osseointegration capacities. One strategy to overcome this limitation is the coating of Ti with hydroxyapatite (HA), which presents similar chemical composition than bone. Nonetheless, most of the strategies currently used generate a non-stable coating and may produce the formation of amorphous phases when high temperatures are used. Herein, we proposed to generate a Ti-HA composite coating on Ti surface to improve the stability of the bioactive coating. The coating was produced by cold gas spraying, which uses relatively low temperatures, and compared to a Ti coating. The coating was thoroughly characterized in terms of morphology, roughness, porosity and phase composition. In addition, the coating was mechanically characterized using a tensile loading machine. Finally, biological response was evaluated after seeding SaOS-2 osteoblasts and measuring cell adhesion, proliferation and differentiation. The novel Ti-HA coating presented high porosity and high adhesion and bond strengths. No change in HA phases was observed after coating formation. Moreover, osteoblast-like cells adhered, proliferated and differentiated on Ti-HA coated surfaces suggesting that the novel coating might be a good candidate for biomedical applications. |
| doi_str_mv | 10.1016/j.colsurfb.2019.04.048 |
| format | Article |
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•A titanium-hydroxyapatite coating was produced on titanium by Cold Gas Spray.•Higher adhesion and bond strengths values were obtained compared to other methods.•Cold Gas Spray does not produce any change in hydroxyapatite and titanium phases.•Osteoblasts adhere, proliferate and differentiate on the Ti-HA coated surfaces.
The lack of bioactivity of titanium (Ti) is one of the main drawbacks for its application in biomedical implants since it can considerable reduce its osseointegration capacities. One strategy to overcome this limitation is the coating of Ti with hydroxyapatite (HA), which presents similar chemical composition than bone. Nonetheless, most of the strategies currently used generate a non-stable coating and may produce the formation of amorphous phases when high temperatures are used. Herein, we proposed to generate a Ti-HA composite coating on Ti surface to improve the stability of the bioactive coating. The coating was produced by cold gas spraying, which uses relatively low temperatures, and compared to a Ti coating. The coating was thoroughly characterized in terms of morphology, roughness, porosity and phase composition. In addition, the coating was mechanically characterized using a tensile loading machine. Finally, biological response was evaluated after seeding SaOS-2 osteoblasts and measuring cell adhesion, proliferation and differentiation. The novel Ti-HA coating presented high porosity and high adhesion and bond strengths. No change in HA phases was observed after coating formation. Moreover, osteoblast-like cells adhered, proliferated and differentiated on Ti-HA coated surfaces suggesting that the novel coating might be a good candidate for biomedical applications.</description><identifier>ISSN: 0927-7765</identifier><identifier>EISSN: 1873-4367</identifier><identifier>DOI: 10.1016/j.colsurfb.2019.04.048</identifier><identifier>PMID: 31055151</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Bioactivity ; Biomedical materials ; Biomedical Technology - methods ; Cell Line ; Coated Materials, Biocompatible - chemistry ; Cold gas spray ; Cold Temperature ; Durapatite - chemistry ; Enginyeria biomèdica ; Gases - chemistry ; Humans ; Hydroxyapatite coating ; Materials biomèdics ; Osteoblast-like cells ; Osteoblasts - cytology ; Porosity ; Solutions ; Surface Properties ; Tensile Strength ; Titanium ; Titanium - chemistry ; X-Ray Diffraction ; Àrees temàtiques de la UPC</subject><ispartof>Colloids and surfaces, B, Biointerfaces, 2019-08, Vol.180, p.245-253</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><rights>Attribution-NonCommercial-NoDerivs 3.0 Spain info:eu-repo/semantics/openAccess <a href="http://creativecommons.org/licenses/by-nc-nd/3.0/es/">http://creativecommons.org/licenses/by-nc-nd/3.0/es/</a></rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-fd61e592b94483bd82ea41ab9cd182b0976397cf1f0c288c82c0e7619cbe4b1f3</citedby><cites>FETCH-LOGICAL-c495t-fd61e592b94483bd82ea41ab9cd182b0976397cf1f0c288c82c0e7619cbe4b1f3</cites><orcidid>0000-0003-0307-2221</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.colsurfb.2019.04.048$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,26973,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31055151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guillem-Marti, Jordi</creatorcontrib><creatorcontrib>Cinca, Núria</creatorcontrib><creatorcontrib>Punset, Miquel</creatorcontrib><creatorcontrib>Cano, Irene García</creatorcontrib><creatorcontrib>Gil, Francisco Javier</creatorcontrib><creatorcontrib>Guilemany, Jose Maria</creatorcontrib><creatorcontrib>Dosta, Sergi</creatorcontrib><title>Porous titanium-hydroxyapatite composite coating obtained on titanium by cold gas spray with high bond strength for biomedical applications</title><title>Colloids and surfaces, B, Biointerfaces</title><addtitle>Colloids Surf B Biointerfaces</addtitle><description>[Display omitted]
•A titanium-hydroxyapatite coating was produced on titanium by Cold Gas Spray.•Higher adhesion and bond strengths values were obtained compared to other methods.•Cold Gas Spray does not produce any change in hydroxyapatite and titanium phases.•Osteoblasts adhere, proliferate and differentiate on the Ti-HA coated surfaces.
The lack of bioactivity of titanium (Ti) is one of the main drawbacks for its application in biomedical implants since it can considerable reduce its osseointegration capacities. One strategy to overcome this limitation is the coating of Ti with hydroxyapatite (HA), which presents similar chemical composition than bone. Nonetheless, most of the strategies currently used generate a non-stable coating and may produce the formation of amorphous phases when high temperatures are used. Herein, we proposed to generate a Ti-HA composite coating on Ti surface to improve the stability of the bioactive coating. The coating was produced by cold gas spraying, which uses relatively low temperatures, and compared to a Ti coating. The coating was thoroughly characterized in terms of morphology, roughness, porosity and phase composition. In addition, the coating was mechanically characterized using a tensile loading machine. Finally, biological response was evaluated after seeding SaOS-2 osteoblasts and measuring cell adhesion, proliferation and differentiation. The novel Ti-HA coating presented high porosity and high adhesion and bond strengths. No change in HA phases was observed after coating formation. Moreover, osteoblast-like cells adhered, proliferated and differentiated on Ti-HA coated surfaces suggesting that the novel coating might be a good candidate for biomedical applications.</description><subject>Bioactivity</subject><subject>Biomedical materials</subject><subject>Biomedical Technology - methods</subject><subject>Cell Line</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Cold gas spray</subject><subject>Cold Temperature</subject><subject>Durapatite - chemistry</subject><subject>Enginyeria biomèdica</subject><subject>Gases - chemistry</subject><subject>Humans</subject><subject>Hydroxyapatite coating</subject><subject>Materials biomèdics</subject><subject>Osteoblast-like cells</subject><subject>Osteoblasts - cytology</subject><subject>Porosity</subject><subject>Solutions</subject><subject>Surface Properties</subject><subject>Tensile Strength</subject><subject>Titanium</subject><subject>Titanium - chemistry</subject><subject>X-Ray Diffraction</subject><subject>Àrees temàtiques de la UPC</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>XX2</sourceid><recordid>eNqFUcFu3CAQRVWjZpP2FyKOvXjDYGzg1ipq00qR2kN6RoDxLivbuIDb-hv602G1m_RYaRDD8N7M6D2EboBsgUB7e9jaMKQl9mZLCcgtYSXEK7QBweuK1S1_jTZEUl5x3jaX6CqlAyGEMuBv0GUNpGmggQ36-z3EsCScfdaTX8Zqv3Yx_Fn1rEvJYRvGOaRTVirTDgeTtZ9ch8P0wsJmLf9Dh3c64TRHveLfPu_x3u_22ISpwylHN-1KqQ8RGx9G13mrB6zneShJ9mFKb9FFr4fk3p3va_Tj86fHuy_Vw7f7r3cfHyrLZJOrvmvBNZIayZioTSeo0wy0kbYDQQ2RvK0ltz30xFIhrKCWON6CtMYxA319jeDU16bFquisi2UDFbT_9zgeSjhVdcOBtYXz_sSZY_i5uJTV6JN1w6AnV_RTlNYgSU2bpkDbc_sYUoquV3P0o46rAqKO5qmDejZPHc1ThJUQhXhznrGYos8L7dmtAvhwAriizi_vokrWu8kWLcviWXXB_2_GE_WSsog</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Guillem-Marti, Jordi</creator><creator>Cinca, Núria</creator><creator>Punset, Miquel</creator><creator>Cano, Irene García</creator><creator>Gil, Francisco Javier</creator><creator>Guilemany, Jose Maria</creator><creator>Dosta, Sergi</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>XX2</scope><orcidid>https://orcid.org/0000-0003-0307-2221</orcidid></search><sort><creationdate>20190801</creationdate><title>Porous titanium-hydroxyapatite composite coating obtained on titanium by cold gas spray with high bond strength for biomedical applications</title><author>Guillem-Marti, Jordi ; Cinca, Núria ; Punset, Miquel ; Cano, Irene García ; Gil, Francisco Javier ; Guilemany, Jose Maria ; Dosta, Sergi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-fd61e592b94483bd82ea41ab9cd182b0976397cf1f0c288c82c0e7619cbe4b1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Bioactivity</topic><topic>Biomedical materials</topic><topic>Biomedical Technology - methods</topic><topic>Cell Line</topic><topic>Coated Materials, Biocompatible - chemistry</topic><topic>Cold gas spray</topic><topic>Cold Temperature</topic><topic>Durapatite - chemistry</topic><topic>Enginyeria biomèdica</topic><topic>Gases - chemistry</topic><topic>Humans</topic><topic>Hydroxyapatite coating</topic><topic>Materials biomèdics</topic><topic>Osteoblast-like cells</topic><topic>Osteoblasts - cytology</topic><topic>Porosity</topic><topic>Solutions</topic><topic>Surface Properties</topic><topic>Tensile Strength</topic><topic>Titanium</topic><topic>Titanium - chemistry</topic><topic>X-Ray Diffraction</topic><topic>Àrees temàtiques de la UPC</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guillem-Marti, Jordi</creatorcontrib><creatorcontrib>Cinca, Núria</creatorcontrib><creatorcontrib>Punset, Miquel</creatorcontrib><creatorcontrib>Cano, Irene García</creatorcontrib><creatorcontrib>Gil, Francisco Javier</creatorcontrib><creatorcontrib>Guilemany, Jose Maria</creatorcontrib><creatorcontrib>Dosta, Sergi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Recercat</collection><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guillem-Marti, Jordi</au><au>Cinca, Núria</au><au>Punset, Miquel</au><au>Cano, Irene García</au><au>Gil, Francisco Javier</au><au>Guilemany, Jose Maria</au><au>Dosta, Sergi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Porous titanium-hydroxyapatite composite coating obtained on titanium by cold gas spray with high bond strength for biomedical applications</atitle><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle><addtitle>Colloids Surf B Biointerfaces</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>180</volume><spage>245</spage><epage>253</epage><pages>245-253</pages><issn>0927-7765</issn><eissn>1873-4367</eissn><abstract>[Display omitted]
•A titanium-hydroxyapatite coating was produced on titanium by Cold Gas Spray.•Higher adhesion and bond strengths values were obtained compared to other methods.•Cold Gas Spray does not produce any change in hydroxyapatite and titanium phases.•Osteoblasts adhere, proliferate and differentiate on the Ti-HA coated surfaces.
The lack of bioactivity of titanium (Ti) is one of the main drawbacks for its application in biomedical implants since it can considerable reduce its osseointegration capacities. One strategy to overcome this limitation is the coating of Ti with hydroxyapatite (HA), which presents similar chemical composition than bone. Nonetheless, most of the strategies currently used generate a non-stable coating and may produce the formation of amorphous phases when high temperatures are used. Herein, we proposed to generate a Ti-HA composite coating on Ti surface to improve the stability of the bioactive coating. The coating was produced by cold gas spraying, which uses relatively low temperatures, and compared to a Ti coating. The coating was thoroughly characterized in terms of morphology, roughness, porosity and phase composition. In addition, the coating was mechanically characterized using a tensile loading machine. Finally, biological response was evaluated after seeding SaOS-2 osteoblasts and measuring cell adhesion, proliferation and differentiation. The novel Ti-HA coating presented high porosity and high adhesion and bond strengths. No change in HA phases was observed after coating formation. Moreover, osteoblast-like cells adhered, proliferated and differentiated on Ti-HA coated surfaces suggesting that the novel coating might be a good candidate for biomedical applications.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>31055151</pmid><doi>10.1016/j.colsurfb.2019.04.048</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0307-2221</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Colloids and surfaces, B, Biointerfaces, 2019-08, Vol.180, p.245-253 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); Recercat |
| subjects | Bioactivity Biomedical materials Biomedical Technology - methods Cell Line Coated Materials, Biocompatible - chemistry Cold gas spray Cold Temperature Durapatite - chemistry Enginyeria biomèdica Gases - chemistry Humans Hydroxyapatite coating Materials biomèdics Osteoblast-like cells Osteoblasts - cytology Porosity Solutions Surface Properties Tensile Strength Titanium Titanium - chemistry X-Ray Diffraction Àrees temàtiques de la UPC |
| title | Porous titanium-hydroxyapatite composite coating obtained on titanium by cold gas spray with high bond strength for biomedical applications |
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